/* Jamming Physics — VP Disease Emergence Kit (therapeutic-direction volume)
   House style inherited from the Jamming Physics whitepaper family:
   instrument-grade academic, claim-strip signature, grade badges [F]/[V]/[L]/[O].
   Volume signature: the Rx-firewall — an unmissable bilingual regulatory notice
   that frames every page as a DIRECTION offered to experts, never a prescription.
   No build step, no JS dependency: static, accessible, reduced-motion-safe. */

:root{
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  --paper:#fbfaf7; --panel:#f3f1ea; --line:#dcd8cf; --line-soft:#e9e6df;
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  --g-forced:#7a4d00;   --g-forced-bg:#f3e6cf;
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  --c-pipe:#1c5b86;   --c-pipe-bg:#e6f0f8;   --c-pipe-ln:#1c5b86;
  /* hazard */
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  --mono:"SF Mono","Roboto Mono","DejaVu Sans Mono",ui-monospace,Menlo,Consolas,monospace;
}

*{box-sizing:border-box}
html{font-size:18px;-webkit-text-size-adjust:100%}
body{
  margin:0;background:var(--paper);color:var(--ink);
  font-family:var(--serif);line-height:1.62;
  font-feature-settings:"kern" 1,"liga" 1,"onum" 1;
}

/* ---- shell ---- */
header{border-bottom:1px solid var(--line);background:var(--paper)}
nav.crumb{
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}
nav.crumb a{color:var(--accent);text-decoration:none}
nav.crumb a:hover{text-decoration:underline}
main{max-width:var(--maxw);margin:0 auto;padding:2.2rem 1.25rem 1rem}
footer{
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}
footer a{color:var(--accent);text-decoration:none}

/* ---- type ---- */
h1{
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}
h2{
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}
h2::before{
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}
h3{
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  margin:1.6rem 0 .55rem;color:var(--ink-soft);
}
p{margin:0 0 1rem}
a{color:var(--accent)}
strong,b{font-weight:650}
sup,sub{line-height:0}

/* answer-first: the lede the retrieval engine extracts */
p.answer{
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  color:var(--ink);background:var(--accent-soft);
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}
p.abstract{color:var(--ink-soft);font-size:1.02rem;margin:0 0 1.2rem}

/* ====================================================================
   Rx-FIREWALL — the volume signature (top + bottom, bilingual)
   ==================================================================== */
.rx-banner{
  font-family:var(--sans);border:2px solid var(--hz);border-radius:8px;
  background:
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  margin:0 0 1.5rem;overflow:hidden;
}
.rx-banner.bottom{margin:2rem 0 0}
.rx-banner .hd{
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  letter-spacing:.04em;text-transform:uppercase;padding:.5rem .9rem;
  display:flex;align-items:center;gap:.5rem;
}
.rx-banner .hd .mk{font-size:1rem;line-height:1}
.rx-banner .bd{padding:.8rem .95rem;background:#fffefdcc}
.rx-banner ul{margin:0;padding-left:1.1rem;list-style:none}
.rx-banner li{margin:.42rem 0;font-size:.86rem;line-height:1.5;position:relative;padding-left:.2rem}
.rx-banner li::before{content:"▪";color:var(--hz);position:absolute;left:-.95rem;top:.05rem}
.rx-banner .em{font-weight:700;color:var(--hz)}
.rx-banner .dose{
  margin:.6rem 0 0;padding:.6rem .75rem;border-top:1px dashed var(--hz-stripe);
  background:#fff;border-radius:0 0 5px 5px;font-size:.85rem;
}
.rx-banner .dose b{color:var(--hz)}

/* inline beside-drug notice (warning #2) */
.rx-inline{
  font-family:var(--sans);font-size:.78rem;line-height:1.45;color:var(--hz);
  background:var(--hz-bg);border:1px solid var(--hz-stripe);border-radius:5px;
  padding:.4rem .6rem;margin:.45rem 0 .2rem;display:block;
}
.rx-inline .mk{font-weight:700}

/* ---- claim-strip: family signature ---- */
aside.claim-strip{
  display:flex;flex-wrap:wrap;align-items:center;gap:.55rem .85rem;
  font-family:var(--sans);font-size:.78rem;
  border:1px solid var(--line);background:var(--panel);border-radius:6px;
  padding:.6rem .85rem;margin:0 0 1.5rem;
}
aside.claim-strip a{color:var(--accent);text-decoration:none;font-weight:550}
aside.claim-strip a:hover{text-decoration:underline}
.claim-strip .gate{color:var(--faint);letter-spacing:.01em}
.claim-strip .doi{color:var(--accent);font-weight:550}

.grade{
  font-weight:700;letter-spacing:.02em;padding:.12rem .5rem;border-radius:999px;
  font-size:.72rem;text-transform:uppercase;white-space:nowrap;
}
.g-forced{color:var(--g-forced);background:var(--g-forced-bg)}
.g-verified{color:var(--g-verified);background:var(--g-verified-bg)}
.g-calibrated{color:var(--g-calibrated);background:var(--g-calibrated-bg)}
.g-open{color:var(--g-open);background:var(--g-open-bg)}
.g-hypothesis{color:var(--g-hyp);background:var(--g-hyp-bg)}

/* ---- vp-card: a locked quantity restated self-containedly ---- */
aside.vp-card{
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  border:1px solid var(--line-soft);border-left:3px solid var(--g-calibrated);
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}
aside.vp-card b{color:var(--ink);font-family:var(--mono);font-size:.86rem}
aside.vp-card a{color:var(--accent);text-decoration:none;font-weight:550}
aside.vp-card a:hover{text-decoration:underline}

/* honest-boundary callout */
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}
.bound b{color:var(--ink)}

/* ---- cusp box ---- */
.cusp{
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}
.cusp dl{display:grid;grid-template-columns:auto 1fr;gap:.25rem .8rem;margin:0}
.cusp dt{color:var(--faint);font-family:var(--mono);font-size:.8rem}
.cusp dd{margin:0;font-variant-numeric:tabular-nums;color:var(--ink)}

/* ---- classification badges + agent cards ---- */
.cbadge{
  font-family:var(--sans);font-weight:700;font-size:.7rem;letter-spacing:.02em;
  text-transform:uppercase;border-radius:999px;padding:.12rem .5rem;white-space:nowrap;
}
.cb-match{color:var(--c-match);background:var(--c-match-bg);border:1px solid #0b6b5e44}
.cb-novel{color:var(--c-novel);background:var(--c-novel-bg);border:1px solid #5b2a8644}
.cb-hold{color:var(--c-hold);background:var(--c-hold-bg);border:1px solid #9aa1ab66}
.cb-pipe{color:var(--c-pipe);background:var(--c-pipe-bg);border:1px solid #1c5b8644}

.agent{
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}
.agent.match{border-left-color:var(--c-match-ln)}
.agent.novel{border-left-color:var(--c-novel-ln)}
.agent.pipe{border-left-color:var(--c-pipe-ln)}
.agent .hd{display:flex;flex-wrap:wrap;gap:.4rem .6rem;align-items:center;margin-bottom:.3rem}
.agent .nm{font-family:var(--sans);font-weight:700;font-size:.94rem;color:var(--ink)}
.agent .meta{font-family:var(--sans);font-size:.8rem;color:var(--ink-soft);margin:.18rem 0}
.agent .meta b{color:var(--ink)}
.agent .fal{
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  background:var(--panel);border-left:3px solid var(--g-open);border-radius:0 4px 4px 0;
  padding:.4rem .6rem;margin:.35rem 0 .2rem;
}
.agent .fal b{color:var(--g-open)}
.agent .src{font-family:var(--sans);font-size:.78rem;color:var(--faint);margin:.3rem 0 0}

/* match recovery callout */
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}
.recover b{color:var(--c-match)}

/* ---- tables ---- */
.tbl-wrap{overflow-x:auto;margin:1.1rem 0}
table{border-collapse:collapse;width:100%;font-family:var(--sans);font-size:.82rem;line-height:1.45}
caption{caption-side:top;text-align:left;font-family:var(--sans);font-size:.78rem;color:var(--faint);margin-bottom:.4rem}
th,td{text-align:left;padding:.45rem .7rem;border-bottom:1px solid var(--line-soft);vertical-align:top}
thead th{border-bottom:1.5px solid var(--line);color:var(--ink);font-weight:650;white-space:nowrap}
tbody tr:last-child td{border-bottom:1px solid var(--line)}
td code,th code,p code,li code{font-family:var(--mono);font-size:.84em;background:var(--panel);padding:.05rem .3rem;border-radius:3px}
.num{font-variant-numeric:tabular-nums;white-space:nowrap}

/* ---- stat bars (CSS-only, no JS) ---- */
.stat{margin:1.1rem 0}
.stat .row{display:grid;grid-template-columns:13rem 1fr 3.4rem;gap:.6rem;align-items:center;margin:.32rem 0;font-family:var(--sans);font-size:.82rem}
.stat .lab{color:var(--ink-soft)}
.stat .bar{height:.95rem;border-radius:3px;background:var(--accent);min-width:2px}
.stat .bar.match{background:var(--c-match)}
.stat .bar.novel{background:var(--c-novel)}
.stat .bar.hold{background:var(--c-hold-ln)}
.stat .bar.alt{background:var(--g-calibrated)}
.stat .val{text-align:right;font-variant-numeric:tabular-nums;color:var(--faint)}
@media (max-width:34rem){.stat .row{grid-template-columns:8.5rem 1fr 3rem}}

/* ---- lists ---- */
ul,ol{margin:0 0 1.1rem;padding-left:1.3rem}
li{margin:.3rem 0}

/* ---- prev/next nav ---- */
nav.pn{
  display:flex;flex-wrap:wrap;gap:.6rem 1rem;justify-content:space-between;align-items:center;
  font-family:var(--sans);font-size:.84rem;border-top:1px solid var(--line);padding-top:1.1rem;margin-top:2.4rem;
}
nav.pn a{color:var(--accent);text-decoration:none;font-weight:550}
nav.pn a:hover{text-decoration:underline}
nav.pn a.center{color:var(--faint);font-weight:500}

/* ---- hub & index ---- */
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  font-family:var(--sans);font-size:.86rem;color:var(--ink-soft);
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}
.derive-line a{font-weight:600;text-decoration:none}

ol.toc{list-style:none;padding:0;margin:1.2rem 0 0;counter-reset:ch}
ol.toc li{margin:0;border-bottom:1px solid var(--line-soft);padding:.7rem 0;display:grid;grid-template-columns:2.4rem 1fr auto;gap:.5rem 1rem;align-items:baseline}
ol.toc li::before{counter-increment:ch;content:"§" counter(ch,decimal-leading-zero);font-family:var(--mono);font-size:.82rem;color:var(--faint)}
ol.toc a{font-family:var(--serif);font-size:1.02rem;text-decoration:none;color:var(--ink);font-weight:500}
ol.toc a:hover{color:var(--accent);text-decoration:underline}
ol.toc .one{display:block;font-family:var(--sans);font-size:.8rem;color:var(--ink-soft);margin-top:.2rem;font-weight:400}
ol.toc .gcell{justify-self:end}

/* A–Z disease index */
.azbar{display:flex;flex-wrap:wrap;gap:.3rem;font-family:var(--mono);font-size:.82rem;margin:1.1rem 0 1.6rem}
.azbar a{display:inline-block;min-width:1.7rem;text-align:center;padding:.18rem .25rem;border:1px solid var(--line);border-radius:4px;text-decoration:none;color:var(--accent);background:#fff}
.azbar a:hover{background:var(--accent-soft)}
.azbar span{display:inline-block;min-width:1.7rem;text-align:center;padding:.18rem .25rem;color:var(--faint)}

ul.dzlist{list-style:none;padding:0;margin:1rem 0 0}
ul.dzlist li{border-bottom:1px solid var(--line-soft);padding:.6rem 0;display:grid;grid-template-columns:1fr auto;gap:.4rem 1rem;align-items:baseline}
ul.dzlist a{font-family:var(--serif);font-size:1.0rem;text-decoration:none;color:var(--ink);font-weight:500}
ul.dzlist a:hover{color:var(--accent);text-decoration:underline}
ul.dzlist .one{display:block;font-family:var(--sans);font-size:.79rem;color:var(--ink-soft);margin-top:.18rem;font-weight:400}
ul.dzlist .gene{font-family:var(--mono);font-size:.74rem;color:var(--faint)}

.legend{display:flex;flex-wrap:wrap;gap:.5rem .8rem;font-family:var(--sans);font-size:.76rem;color:var(--ink-soft);margin:1.4rem 0;padding:.8rem .9rem;border:1px solid var(--line-soft);border-radius:6px;background:var(--panel)}
.legend span.k{display:inline-flex;align-items:center;gap:.4rem}

/* big landing number */
.hero-stat{display:flex;flex-wrap:wrap;gap:1.4rem 2.2rem;align-items:flex-end;margin:1.4rem 0 1.8rem;padding:1.2rem 0;border-top:1px solid var(--line);border-bottom:1px solid var(--line)}
.hero-stat .n{font-family:var(--serif);font-size:2.6rem;font-weight:600;line-height:1;color:var(--accent);font-variant-numeric:tabular-nums}
.hero-stat .n small{display:block;font-family:var(--sans);font-size:.74rem;font-weight:500;color:var(--ink-soft);text-transform:uppercase;letter-spacing:.03em;margin-top:.35rem}
.hero-stat .n.match{color:var(--c-match)}
.hero-stat .n.novel{color:var(--c-novel)}
.hero-stat .n.hold{color:var(--c-hold)}

/* ---- responsive ---- */
@media (max-width:34rem){
  html{font-size:17px}
  main{padding:1.7rem 1.05rem 1rem}
  h1{font-size:1.5rem}
  ol.toc li{grid-template-columns:2rem 1fr}
  ol.toc .gcell{grid-column:2;justify-self:start;margin-top:.35rem}
  .cusp dl{grid-template-columns:1fr}
  .hero-stat .n{font-size:2.1rem}
}

/* ---- a11y ---- */
a:focus-visible,.toc a:focus-visible{outline:2px solid var(--accent);outline-offset:2px;border-radius:2px}
@media (prefers-reduced-motion:reduce){*{scroll-behavior:auto}}
@media print{
  body{background:#fff}
  aside.claim-strip,nav.pn,nav.crumb{break-inside:avoid}
  .rx-banner{break-inside:avoid}
}