In Progressive familial intrahepatic cholestasis 1 (ATP8B1, OMIM 211600), the master switch sits on the ↑ UP branch ([F] forced below); the healthy state is the ON well. The forced corrective direction is to raise s toward ON branch (polarity: clear). Classification: ✓ Recovers an existing standard. Direction only — no dose, no efficacy magnitude.
The disease maps to an R19 double-well whose corrective lever is read straight off the cusp (barrier 0.5595, γ 1.4960, spinodal 0.7043). The corrective direction is forced [F]; the agent names below are direction-concordant labels at grade [O] (no dose, no efficacy or safety magnitude). This is a research hypothesis offered to experts, not medical advice.
The emergence switch
The switch for Progressive familial intrahepatic cholestasis 1 is an R19 double-well emerged from the real proximal-promoter DNA of ATP8B1. Its geometry is fixed by measured stiffness γ (never fitted); the numbers below are read directly off that cusp.
emergent axis
↑ UP [F]
healthy branch
ON
lesion
LOF_null
γ (stiffness)
1.4960
barrier
0.5595
spinodal
0.7043
s_on / s_off
1.2231 / -1.2231
fragility
0.18
corrective polarity
clear
forced direction
raise s toward ON branch
Chemistry feasibility (DIRECTION only [O]). small-molecule recrossing of the fold is geometrically harder (barrier 0.5595 at neutral drive; lower barrier = smaller drive to supply). [O] -- no affinity/potency/dose/efficacy asserted.
The derived corrective lever
The cusp forces a corrective direction: raise s toward ON branch. This is the load-bearing output of the framework — it is [F] forced, and it is falsifiable. 2 lever families are derived; the lead is h-restore (drive modulator).
Mechanism. remove / oppose the drive (clear the accumulating load that pins the disease branch)
Applies to. allele-agnostic (downstream/environmental tilt)
favoured when the switch is fragile -- a small drive shift recrosses the fold
Falsifier. If clearing/opposing the accumulating pathological accumulation / over-activity from the ATP8B1 LOF lesion does NOT relieve the disease branch in a ATP8B1 model, the h-restore(clear) lever is refuted for this axis.
Falsifier. If a folding-stabiliser/chaperone does NOT re-deepen the healthy well for a residual ATP8B1 allele (no rescue that a null allele lacks), the gamma-restore lever is refuted; null alleles are excluded by construction.
Agents mapped onto the lever
✓ Agreement with established practice. The corrective direction derived here (raise s toward ON branch) independently matches an agent already in clinical use for this disease: ileal bile-acid transporter (IBAT) inhibitor (odevixibat) reducing the enterohepatic bile-acid load that accumulates downstream of the ATP8B1 canalicular-flippase defect. The geometry recovered known medicine — this is a validation signal for the logic, not a new treatment claim by this kit.
Existing agents whose known action is direction-concordant with the derived lever (status as pinned in the corpus; no dose, no efficacy magnitude).
agent (class)
dir.
status
phase
map
ileal bile-acid transporter (IBAT) inhibitor (odevixibat) reducing the enterohepatic bile-acid load that accumulates downstream of the ATP8B1 canalicular-flippase defect
Laue 2022 Expert Opin Investig Drugs 31:1143 (Odevixibat: an investigational inhibitor of the ileal bile acid transporter (IBAT) for the treatment of biliary atresia); Klomp 2000 Hepatology 32:1337 (A missense mutation in FIC1 is associated with greenland familial cholestasis)
decrease
approved
4
✓ in use
⚠ Mechanism-direction only — do not self-administer; no dose (unvalidated; set by a physician / national authority); not an approved use.
Direction-only candidate leads (corpus join)
Each lead is surfaced only because its known mechanism points the same way as the derived lever, and each comes with a source and a falsifier. None is a treatment.
Mechanism. ileal bile-acid transporter (IBAT) inhibitor (odevixibat) reducing the enterohepatic bile-acid load that accumulates downstream of the ATP8B1 canalicular-flippase defect Direction: decrease the pathological accumulation / over-activity. Scope: agnostic (downstream).
✓ This is a rediscovery. Odevixibat (IBAT inhibitor) is approved for progressive familial intrahepatic cholestasis (incl. the ATP8B1/PFIC1 form); approved therapy recovered.
Safety (qualitative; no magnitude). established-use safety profile on record (qualitative; no magnitude)
Falsifier. If odevixibat (IBAT inhibitor) [ATP8B1 Progressive familial intrahepatic cholestasis 1] (a gene-specific decrease agent) clearing/opposing the accumulating load does NOT relieve the UP [F] disease branch in a ATP8B1 model, the h-restore(clear) direction is refuted for odevixibat (IBAT inhibitor) [ATP8B1 Progressive familial intrahepatic cholestasis 1] here.
Source: Laue 2022 Expert Opin Investig Drugs 31:1143 (Odevixibat: an investigational inhibitor of the ileal bile acid transporter (IBAT) for the treatment of biliary atresia)
⚠ Mechanism-direction only — do not self-administer; no dose (unvalidated; set by a physician / national authority); not an approved use.
Evidence & provenance
What is reproduced vs. cited for this page.
element
grade
basis
R19 switch & cusp geometry (this page)
[V] verified
emerged from measured promoter γ of ATP8B1; deterministic, 2×sha256 identical
corrective direction
[F] forced
forced by the cusp sign; falsifiable (see lever falsifiers)
mapped agents / leads
[O] open
direction-concordance only; corpus-pinned (2026-06-21); no dose, no efficacy/safety magnitude
Reading the agent column. VALIDATION SIGNAL -- the agent is already approved / established standard for this disease, so the direction logic recovered known clinical practice. Not a new claim by this kit. GENUINE HYPOTHESIS -- no approved indication for this disease; the direction match is a direction-only, untested [O] lead. Basis field grades the evidence (investigational here / in a related condition / off-label / speculative).