RP (MERTK) OMIM 613862

In RP (MERTK, OMIM 613862), the master switch sits on the ↓ DOWN branch (cited role × mechanism, below); the healthy state is the ON well. The forced corrective direction is to raise s toward ON branch (polarity: supply). Classification: — Honest hold (no matched agent). Direction only — no dose, no efficacy magnitude.

The disease maps to an R19 double-well whose corrective lever is read straight off the cusp (barrier 0.5661, γ 1.5048, spinodal 0.7105). The corrective direction is an interpretation of the model (a code output whose sign follows from the cited lesion role and mechanism); the agent names below are direction-concordant labels at grade [O] (no dose, no efficacy or safety magnitude). This is a research hypothesis offered to experts, not medical advice.

The emergence switch

The switch for RP is an R19 double-well emerged from the real proximal-promoter DNA of MERTK. Its geometry is fixed by measured stiffness γ (never fitted); the numbers below are read directly off that cusp.

emergent axis: ↓ DOWN (cited role × mechanism)
healthy branch: ON
lesion: LOF_null
γ (stiffness): 1.5048
barrier: 0.5661
spinodal: 0.7105
s_on / s_off: 1.2267 / -1.2267
fragility: 0.15
corrective polarity: supply
forced direction: raise s toward ON branch

Chemistry feasibility (DIRECTION only [O]). small-molecule recrossing of the fold is geometrically harder (barrier 0.5661 at neutral drive; lower barrier = smaller drive to supply). [O] -- no affinity/potency/dose/efficacy asserted.

The derived corrective lever

The cusp forces a corrective direction: raise s toward ON branch. This is the load-bearing output of the framework — an interpretation of the model (code output, not a forced biological fact), and it is falsifiable. 2 lever families are derived; the lead is h-restore (drive modulator).

h-restore (drive modulator)sign: increasegeometric rank 0.15

Mechanism. supply / restore the positive drive (replace-or-agonise the missing competence)

Applies to. allele-agnostic (downstream/environmental tilt)

favoured when the switch is fragile -- a small drive shift recrosses the fold

Falsifier. If supplying/agonising deficient MER receptor tyrosine kinase for RPE phagocytosis competence lost to the MERTK LOF defect (raising the switch drive) does NOT move the DOWN switch toward the healthy branch in a MERTK-deficient model, the h-restore(supply) lever is refuted for this axis.

gamma-restore (stabiliser / chaperone)sign: Nonegeometric rank 0.00

Mechanism. N/A

Applies to. none (honest exclusion)

EXCLUDED: null allele -- no product to stiffen

Falsifier. If a folding-stabiliser/chaperone does NOT re-deepen the healthy well for a residual MERTK allele (no rescue that a null allele lacks), the gamma-restore lever is refuted; null alleles are excluded by construction.

Agents mapped onto the lever

Honest hold. The corrective direction is derived and falsifiable, but no approved direction-matched agent is mapped in the pinned corpus. The kit holds here rather than name a weak instance — an honest hold is a finding, not a failure.

Evidence & provenance

What is reproduced vs. cited for this page.
element	grade	basis
R19 switch & cusp geometry (this page)	code output	emerged from measured promoter γ of `MERTK`; deterministic, 2×sha256 identical
corrective direction	interpretation	code output of the model: the sign follows from the cited lesion role × mechanism (which well the disease occupies); falsifiable (see lever falsifiers); magnitude [O]
mapped agents / leads	[O] open	direction-concordance only; corpus-pinned (2026-06-21); no dose, no efficacy/safety magnitude

Reading the agent column. VALIDATION SIGNAL (read: consistency with established practice, partly by construction, since the corrective sign follows from the cited lesion class) -- the agent is already approved / established standard for this disease, so the direction logic agrees with known clinical practice. Not a new claim by this kit. GENUINE HYPOTHESIS -- no approved indication for this disease; the direction match is a direction-only, untested [O] lead. Basis field grades the evidence (investigational here / in a related condition / off-label / speculative).