Hemodynamic Homeostasis · §15 · strengthen baroreflex buffer gain → excursions self-correct toward the lower setpoint

Lever H2: restore the fast restoring buffer (raise the loop’s own correcting current)

Lever H2 restores the fast baroreflex buffer, strengthening PIEZO1/2 stretch-transduction gain so excursions self-correct toward the lower setpoint. It raises the loop’s own error-correcting current rather than fighting the setpoint, so its counter-regulation is structurally low — the analgesic L2 outward-current analogue [V].

Lever H2 is the analgesic L2 analogue: increase the restoring (outward-current) term so the system self-corrects, rather than injecting a disturbance the loop must reject. Restoring baroreflex buffer gain does not fight the setpoint; it improves the loop’s own error-correction, which is why its counter-regulation is structurally low rather than zero — it acts on the fast loop, not on the slow integrator’s reference.

Strengthen the buffer, do not fight the setpoint

Lever H2 acts on the fast baroreflex loop. The package’s RP2 result shows an intact baroreflex buffers the majority of a pressure step (open-loop gain G = 3 buffers about 75%), while PIEZO1/2 double-loss is labile with no buffering. H2 strengthens that buffer gain so excursions self-correct toward whatever setpoint is in force. Because it raises the loop’s own restoring current rather than injecting a sustained operating-point antagonist, the integral controller has little error to reject: its counter-regulation is structurally low. In the analgesic frame this is the L2 lever — increase the outward (restoring) current that returns the element toward rest.

One axis: the PIEZO stretch buffer

The comfort map places a single axis on H2: the baroreflex PIEZO axis, which restores stretch-transduction buffer gain through the PIEZO1/2 mechanosensors that read arterial wall stretch. The sensor identity is the concrete molecular transducer the sensory layer already models; the pharmacology that could restore its gain is cited biology [O], not derived from the loop reading. H2 is most naturally a partner lever: it makes a lower setpoint easier to hold once H1 has reset the reference, by tightening the fast self-correction around it.

Grade and boundary

H2 is graded [V] as a structural direction — raise the loop’s restoring current — read off the proven RP2/RP6 buffering results. Its counter-regulation tier is “low” rather than “free” because it acts within the fast loop rather than on the integrator’s reference. No molecule or exposure is named; tolerability is [O]; the firewall in §20 holds the boundary.