Bear vs human: a present-but-silenced switch

Does the human genome lack the torpor switch, or carry it silenced? The deep hibernator's PDK4 fuel-switch γ (1.3647) is NOT elevated versus non-hibernators (1.4112, 1.4049, 1.4083) -- so γ does not mark hibernation. The torpor program is a PRESENT switch gated by REGULATION, not a special promoter read.

RH4 and Q1's deepest answer. A pre-registered null: PDK4 promoter γ in a deep hibernator is unremarkable among non-hibernators. The fuel-switch is present across the endotherm set, humans included; what differs is regulatory GATING of that present switch, not its sequence-level stiffness.

The null

Deep-hibernator PDK4 γ = 1.3647; non-hibernator PDK4 γ = 1.4112, 1.4049, 1.4083. The hibernator value is not elevated (False). If hibernation lived in the promoter read, the hibernator would stand out. It does not.

Present but silenced

Combined with the torpor-switch chapters, the reading is direct: the bistable switch exists in genomes that never use it. The capability is REGULATORY gating of a present switch -- which is precisely why the question 'can a human be induced into a torpor-like state' is about control signals, not missing genes.

Grades

The reads are [V] and reproduce offline. The interpretation -- a silenced switch held by regulation -- is [O]: the panel places the genes; it does not derive the gating circuitry.