How to read this map

This map starts from one question -- does an organism DEFEND an internal setpoint or TRACK its environment? -- and reads every node from a single measured number (γ, a promoter stiffness read) placed on the shared R19 bistable-switch scale. It is observation only: no evolutionary language, honest grades throughout.

Each node's master gene carries a measured γ (nearest-neighbour stacking energy of its proximal promoter). γ sets the R19 switch threshold |h_sp|; a defended setpoint is a deep R19 basin, a tracked one is shallow. Grades: [F] forced, [V] simulation-verified, [L] measured, [O] open with a stated obstacle.

The one substrate

Every page reads the same primitive: the R19 jamming-lattice bistable switch ds/dt = γs − s³ + h. Two stable states sit at ±√γ; the drive h biases between them; past the spinodal |h_sp| = 2(γ/3)1.5 one state disappears and the flip is discontinuous. A homeostatic setpoint is just the upper basin; defending it means the basin resists an environmental drive.

Observation only

The analysis compares EXTANT species by what their genomes contain and how the R19 loops behave. There is no descent or selection language anywhere -- only presence/absence and measured γ. Where a single gene fails to separate two strategies, that NULL is reported as a finding, not hidden.

The firewall

γ reads promoter switch-threshold STRUCTURE only. It is never a temperature, a metabolic rate, a glucose level, an HbA1c, a dose, or a clinical effect. Those are Layer-2 and graded [O]. The disease and restoration chapters are falsifiable HYPOTHESES, not medical advice.