Restoration lever 1: restore the loop gain
Lever S1 RESTORES the feedback gain: re-sensitise the loop so the effective stiffness g_eff rises back toward g, deepening the basin and raising the crossing threshold. Its candidate nodes are the sensitivity genes -- INSR (insulin signalling), LEPR (leptin feedback), and PPARG (adipocyte insulin sensitivity). Structural direction [F]; clinical magnitude [O].
The analog of analgesic L2 (increase the outward current). Deepening the basin is the direct inverse of the loop-gain drop that defines the disease. Reads [V]; lever placement [F] structural; every clinical magnitude [O]. Hypotheses only.
What S1 does to the law
In §15's law, S1 raises g_eff: barrier = g_eff²/4 grows and spinodal = 2(g_eff/3)1.5 rises, so a crossed loop can re-open its healthy basin and a drifted one is pulled back. This is the only lever that can RE-CROSS a basin that has already flipped (the type-2-diabetes claim).
Candidate nodes (read on the R19 scale)
| target | γ | |hsp| | restoration direction | cited axis |
|---|---|---|---|---|
| INSR | 1.4956 | 0.7040 | restore insulin-signalling gain (insulin sensitisation) -> deepen the euglycemic basin | cited: insulin-resistance / sensitisation axis (clinical glucose-loop literature) |
| LEPR | 1.4554 | 0.6758 | restore leptin feedback gain (re-sensitise the lipostat) -> deepen the adiposity basin | cited: leptin-resistance / lipostat feedback axis |
| PPARG | 1.3902 | 0.6309 | restore adipocyte insulin sensitivity (storage-node disposal) -> deepen disposal basin | cited: PPAR-gamma insulin-sensitising axis |
Firewall
γ places each gene on the switch-threshold scale; it is NOT an insulin dose or a measured sensitivity. The push direction is [F] structural, anchored to the cited clinical axis. No efficacy or dosing is asserted.