Prioritisation: ranking targets, not drugs
Targets are ranked by a small, transparent score over three CITED tiers -- burden, unmet need, and mechanistic directness -- with DECLARED weights (B 0.40, U 0.35, D 0.25). The top target is the shared insulin node. The γ-|hsp| read is carried as structural context and is NEVER folded into the clinical score.
The analog of analgesic M10. Burden and unmet need lead the weights by editorial choice; the ranking is [F] from cited tiers plus declared weights, not a [V] engine output. The firewall forbids equating a promoter-stiffness read with a clinical magnitude, so γ sits beside the score, never inside it.
The ranking
| target | lever | B | U | D | score | γ-|hsp| (context) |
|---|---|---|---|---|---|---|
| INSR | S1 | 5 | 4 | 5 | 4.65 | 0.7040 |
| MC4R | S2 | 4 | 4 | 4 | 4.00 | 0.5522 |
| LEPR | S1 | 4 | 4 | 3 | 3.75 | 0.6758 |
| UCP1 | S2 | 4 | 4 | 3 | 3.75 | 0.6413 |
| PPARG | S1 | 4 | 3 | 4 | 3.65 | 0.6309 |
| PDK4 | S3 | 4 | 4 | 2 | 3.50 | 0.6453 |
| ADRB3 | S2 | 3 | 3 | 3 | 3.00 | 0.6694 |
| GHRL | S2 | 3 | 3 | 3 | 3.00 | 0.6071 |
| TNF | S3 | 3 | 3 | 2 | 2.75 | — |
Declared weights, not tuned
score = 0.40·B + 0.35·U + 0.25·D over cited 1-5 tiers. The weights are an explicit editorial choice (need leads); they were not tuned to produce a desired ordering. Ranking targets -- not drugs -- keeps the output a research prioritisation, not a treatment list.
Firewall
score = w_B*B + w_U*U + w_D*D over CITED 1..5 tiers; the gamma-|h_sp| read is carried as structural context and is NEVER folded into the clinical priority score (a promoter-stiffness read is not a clinical magnitude). Ranking is [F] from cited tiers + declared weights.