§2 · the writable channel
Small RNA is a reversible write of the drive, resolved into measured species
Small RNA writes the drive h, not the ruler γ: it is reversible (payload cleared, the basin returns), it carries two signs (siRNA→OFF, saRNA→ON), and the measured 12-gene carrier atlas is bistable. Resolved by its biogenesis machinery it splits into miRNA, piRNA, tsRNA and m6A — each a signed drive. [V].
On DICER1 (γ = 1.3981, spinodal 0.6363) a held switch flips only past the opposite spinodal at h = -0.6999, and γ is never edited. Production stability orders by machinery barrier, piRNA deepest.
RNA writes the drive, not the ruler
Driving a held switch with an RNA payload flips it only once the drive passes the opposite spinodal — a hysteretic, memory-bearing flip — while γ stays exactly where it was. That is the defining contrast with an edit: a payload moves the state, an edit moves the SET.
Two signs on one channel
The same channel carries opposite signs: a silencing payload drives the switch OFF, an activating payload drives it ON. One physical channel, a signed write — not two mechanisms.
Reversibility is the through-line
Clear the payload and the basin returns; the correction is reversible and tunable. This is why, later, an RNA vaccine needs no edit and Lever B is the reversible therapeutic lever.
Resolved into measured species
"Small RNA" is not one thing. Split by the measured biogenesis machinery, it resolves into four species, each a signed drive whose production stability is set by its machinery barrier. The ordering is read, never an absolute gain.
| species | machinery | mean γ | prod. barrier | germline-restricted |
|---|---|---|---|---|
| m6A_mRNA | METTL3, YTHDF2 | 1.4119 | 0.4984 | no |
| miRNA | DROSHA, DGCR8, DICER1, AGO2, TARBP2 | 1.4520 | 0.5271 | no |
| tsRNA | ANG | 1.4595 | 0.5325 | yes |
| piRNA | PIWIL1, MOV10L1 | 1.4829 | 0.5497 | yes |
The writer/eraser pair is reversible at the mark level too: METTL3 (γ = 1.4104) writes the m6A mark and drives ON, YTHDF2 (γ = 1.4134) erases it and drives OFF — the mark-side twin of payload reversibility. The germline-restricted machinery (piRNA, tsRNA) selects exactly the carriers that can load the gamete; the somatic species cannot.