Methods and reproducibility

Every quantity in this volume is either a measured input (locked and cited) or derived from the locked R19 forms; nothing is fitted to a target. The displayed numbers are regenerated deterministically (seed-fixed, 2×sha256 identical) and a gate confirms the canonical HTML matches the regenerated values with drift 0. Claims are graded [V] simulation-verified, [F] forced, [L] measured anchor, or [O] open with a stated obstacle.

One substrate, measured γ

The shared primitive is the R19 bistable switch ds/dt = g s − s³ + h, with the locked forms spinodal(g) = 2(g/3)^1.5 and barrier(g) = g²/4. A neuron is that switch plus a slow FitzHugh–Nagumo recovery. The material parameter γ is the measured promoter stacking stiffness γ = −mean(NN stacking ΔG, SantaLucia 1998), read read-only from human promoters on the same window/NN table as the DNA volume gene-clock (form ← γ). γ is never fitted.

Determinism and drift 0

The reproduction harness (repro/neuro/run_all.py) runs every module twice and requires identical stdout sha256 (determinism), compares each module hash to a frozen set, and confirms every number the canonical chapters display is reproduced by some module (HTML↔code drift 0). The package-level verify_all.py additionally runs the per-chapter C1 gates and the v1.11 analgesic-inheritance gate.

The analgesic inheritance (§21–§23)

The 27-target analgesic firing-threshold map is INHERITED from analgesic_threshold_logic v2.0 (DOI 10.5281/zenodo.20733420) and re-derived on this volume\u2019s own engine. The inheritance is principled because that sibling was built on this very engine: repro/neuro/_engine/vp_neuro_engine.py is byte-identical to the engine the frozen sibling map was built on, asserted in-module by sha256. Re-deriving all 27 reads on it reproduces the inherited |h_sp| and barrier at the frozen precision, with identical order — drift 0.

Grading and firewall

[V] simulation-verified · [F] forced by the locked forms · [L] measured/cited anchor · [O] open (with a stated obstacle, collected in the irreproducibility ledger). The analgesic firewall is binding: γ reads promoter switch-threshold STRUCTURE only — never a channel voltage, drug potency, dose, in-vivo selectivity, or clinical effect (all [O]); the felt/affective pain is the Felt Cognition volume\u2019s; monogenic pain channelopathies are gene-key entities owned by disease_wp. No molecule is designed and nothing prescribes.