Lever 3 — remove the sensitising drive

Lever 3 — remove the sensitising drive. Lever 3 removes the upstream sensitising drive — nerve-growth-factor (NGF→TrkA) and CGRP signalling that turn up the gain of the pain pathway. For every L3 target, γ only places the gene in the map; the ligand→receptor→sensitisation mechanism is cited biology, never derived by the read, and is enforced as [O] by

This lever groups the targets whose promoter reads place them in the lever 3 — remove the sensitising drive. Each target keeps its own page with its read, grades, citation, and firewall; the lever direction is cited Layer-2 biology, the reads are [V], and all clinical magnitudes are [O].

What this lever does

Lever 3 removes the upstream sensitising drive — nerve-growth-factor (NGF→TrkA) and CGRP signalling that turn up the gain of the pain pathway. For every L3 target, γ only places the gene in the map; the ligand→receptor→sensitisation mechanism is cited biology, never derived by the read, and is enforced as [O] by a fail-closed L3-honesty gate.

Targets in this lever

Each row links to that target's own self-contained page (its read, grades, citation, and firewall).