CALCB — beta-CGRP (ligand)

CALCB (beta-CGRP (ligand)) is a lever-L3 non-opioid analgesic target. Its promoter reads γ = 1.5169, placing it on the firing-threshold scale at |h_sp| = 0.71909; the intervention direction is to block the CGRP sensitising drive. The read is reproducible [V]; the clinical magnitude is open [O].

CALCB is read from its human promoter by the same deterministic engine used across the map (nearest-neighbour stacking energy → γ = 1.5169; R19 scale → |h_sp| = 0.71909). The read places the gene in lever L3; its selectivity is cited Layer-2 biology, and every clinical magnitude (potency, dose, efficacy, safety) is graded [O].

The read

CALCB — beta-CGRP (ligand) sits in the threshold map at γ = 1.5169, |h_sp| = 0.71909 (barrier 0.575246). It belongs to lever L3; the intervention direction is to block the CGRP sensitising drive (beta-CGRP ligand).

selectivity (cited) CGRP isoform (trigeminal/enteric)

burden Tier-1 migraine

Grades

• read [V] reproducible promoter-switch-threshold read
• order [F] forced by reads
• lever [O] cited biology: gamma places the gene in the lever map; the receptor/network mechanism is NOT derived
• mechanism [O] cited biology: gamma places the gene in the lever map; the receptor/network mechanism is NOT derived
• clinical magnitude [O] OPEN — not a voltage, potency, dose, selectivity-in-vivo, or effect

Firewall. γ here is a read of promoter switch-threshold structure only — never this channel's activation voltage, a candidate's potency, a dosing quantity, an in-vivo selectivity, or a clinical effect. Those magnitudes are [O] open.

Source

Russell 2014 Physiol Rev 94:1099 (CGRP physiology) · reproduce the read (engine)

See also: its lever · prioritisation · grading.