Master switch — nociceptor identity

Master switch — nociceptor identity. PRDM12 is the developmental identity switch that specifies the nociceptor lineage; loss-of-function abolishes pain perception (congenital insensitivity). It is listed because the emergence chain reached the nociceptor through it — it is not an acute small-molecule analgesic target. The read is reproducible [V]; the developmental role is cited biology [O] for therapeutics.

This lever groups the targets whose promoter reads place them in the master switch — nociceptor identity. Each target keeps its own page with its read, grades, citation, and firewall; the lever direction is cited Layer-2 biology, the reads are [V], and all clinical magnitudes are [O].

What this lever does

PRDM12 is the developmental identity switch that specifies the nociceptor lineage; loss-of-function abolishes pain perception (congenital insensitivity). It is listed because the emergence chain reached the nociceptor through it — it is not an acute small-molecule analgesic target. The read is reproducible [V]; the developmental role is cited biology [O] for therapeutics.

Targets in this lever

Each row links to that target's own self-contained page (its read, grades, citation, and firewall).