PRDM12 — PRDM12 (transcription factor)

PRDM12 (PRDM12 (transcription factor)) is a lever-master non-opioid analgesic target. Its promoter reads γ = 1.5955, placing it on the firing-threshold scale at |h_sp| = 0.775699; the intervention direction is to developmental: specifies the nociceptor lineage. The read is reproducible [V]; the clinical magnitude is open [O].

PRDM12 is read from its human promoter by the same deterministic engine used across the map (nearest-neighbour stacking energy → γ = 1.5955; R19 scale → |h_sp| = 0.775699). The read places the gene in lever master; its selectivity is cited Layer-2 biology, and every clinical magnitude (potency, dose, efficacy, safety) is graded [O].

The read

PRDM12 — PRDM12 (transcription factor) sits in the threshold map at γ = 1.5955, |h_sp| = 0.775699 (barrier 0.636405). It belongs to lever master; the intervention direction is to developmental: specifies the nociceptor lineage (not an acute lever).

selectivity (cited) nociceptor-specific (developmental, not an acute drug target)

burden cross-cutting (refractory channelopathy anchor)

Grades

• read [V] reproducible promoter-switch-threshold read
• order [F] forced by reads
• lever [O] developmental role cited (master TF; not an acute mechanism)
• mechanism [O] developmental role cited (master TF; not an acute mechanism)
• clinical magnitude [O] OPEN — not a voltage, potency, dose, selectivity-in-vivo, or effect

Firewall. γ here is a read of promoter switch-threshold structure only — never this channel's activation voltage, a candidate's potency, a dosing quantity, an in-vivo selectivity, or a clinical effect. Those magnitudes are [O] open.

Source

Chen 2015 Nat Genet 47:803 (PRDM12 LOF -> congenital insensitivity to pain) · reproduce the read (engine)

See also: its lever · prioritisation · grading.