CACNA1B — Ca_V2.2

CACNA1B (CaV2.2) is a lever-L1 non-opioid analgesic target. Its promoter reads γ = 1.596, placing it on the firing-threshold scale at |h_sp| = 0.776064; the intervention direction is to reduce inward Ca²⁺. The read is reproducible [V]; the clinical magnitude is open [O].

CACNA1B is read from its human promoter by the same deterministic engine used across the map (nearest-neighbour stacking energy → γ = 1.596; R19 scale → |h_sp| = 0.776064). The read places the gene in lever L1; its selectivity is cited Layer-2 biology, and every clinical magnitude (potency, dose, efficacy, safety) is graded [O].

The read

CACNA1B — Ca_V2.2 sits in the threshold map at γ = 1.596, |h_sp| = 0.776064 (barrier 0.636804). It belongs to lever L1; the intervention direction is to reduce inward Ca²⁺ (N-type presynaptic transmitter release).

selectivity (cited) presynaptic DRG terminal (dorsal horn); ziconotide target

burden Tier-3 severe/refractory (intrathecal)

Grades

• read [V] reproducible promoter-switch-threshold read
• order [F] forced by reads
• lever [F] structural lever + direction (anchored to cited agents)
• mechanism [F] structural: peripheral current block raises the firing threshold (anchored to cited agents)
• clinical magnitude [O] OPEN — not a voltage, potency, dose, selectivity-in-vivo, or effect

Firewall. γ here is a read of promoter switch-threshold structure only — never this channel's activation voltage, a candidate's potency, a dosing quantity, an in-vivo selectivity, or a clinical effect. Those magnitudes are [O] open.

Source

ziconotide (Prialt) FDA 2004; Snutch 2005 NeuroRx 2:662 · reproduce the read (engine)

See also: its lever · prioritisation · grading.