CACNA2D1 — alpha2delta-1 (Ca_V auxiliary subunit)

CACNA2D1 (alpha2delta-1 (CaV auxiliary subunit)) is a lever-L1-adjacent non-opioid analgesic target. Its promoter reads γ = 1.4414, placing it on the firing-threshold scale at |h_sp| = 0.666078; the intervention direction is to reduce inward Ca²⁺ via alpha2delta-1. The read is reproducible [V]; the clinical magnitude is open [O].

CACNA2D1 is read from its human promoter by the same deterministic engine used across the map (nearest-neighbour stacking energy → γ = 1.4414; R19 scale → |h_sp| = 0.666078). The read places the gene in lever L1-adjacent; its selectivity is cited Layer-2 biology, and every clinical magnitude (potency, dose, efficacy, safety) is graded [O].

The read

CACNA2D1 — alpha2delta-1 (Ca_V auxiliary subunit) sits in the threshold map at γ = 1.4414, |h_sp| = 0.666078 (barrier 0.519408). It belongs to lever L1-adjacent; the intervention direction is to reduce inward Ca²⁺ via alpha2delta-1 (gabapentinoid target).

selectivity (cited) up-regulated in injured DRG; gabapentin/pregabalin target

burden Tier-1 neuropathic + adjuvant (among most-prescribed)

Grades

• read [V] reproducible promoter-switch-threshold read
• order [F] forced by reads
• lever [F] structural lever + direction (anchored to cited agents)
• mechanism [F] structural: peripheral current block raises the firing threshold (anchored to cited agents)
• clinical magnitude [O] OPEN — not a voltage, potency, dose, selectivity-in-vivo, or effect

Firewall. γ here is a read of promoter switch-threshold structure only — never this channel's activation voltage, a candidate's potency, a dosing quantity, an in-vivo selectivity, or a clinical effect. Those magnitudes are [O] open.

Source

Field 2006 PNAS 103:17537 (alpha2delta-1 is the gabapentinoid target) · reproduce the read (engine)

See also: its lever · prioritisation · grading.