CNR2 — CB2 cannabinoid receptor

CNR2 (CB2 cannabinoid receptor) is a lever-context non-opioid analgesic target. Its promoter reads γ = 1.3698, placing it on the firing-threshold scale at |h_sp| = 0.617069; the intervention direction is to comparator: peripheral CB2 — a non-psychoactive direction. The read is reproducible [V]; the clinical magnitude is open [O].

CNR2 is read from its human promoter by the same deterministic engine used across the map (nearest-neighbour stacking energy → γ = 1.3698; R19 scale → |h_sp| = 0.617069). The read places the gene in lever context; its selectivity is cited Layer-2 biology, and every clinical magnitude (potency, dose, efficacy, safety) is graded [O].

The read

CNR2 — CB2 cannabinoid receptor sits in the threshold map at γ = 1.3698, |h_sp| = 0.617069 (barrier 0.469088). It belongs to lever context; the intervention direction is to comparator: peripheral CB2 — a non-psychoactive direction.

selectivity (cited) peripheral/immune_hematologic CB2 (non-psychoactive)

burden (comparator)

Grades

• read [V] reproducible promoter-switch-threshold read
• order [F] forced by reads
• lever [O] comparator only: read for contrast; NOT a recommended target
• mechanism [O] comparator only: read for contrast; NOT a recommended target
• clinical magnitude [O] OPEN — not a voltage, potency, dose, selectivity-in-vivo, or effect

Firewall. γ here is a read of promoter switch-threshold structure only — never this channel's activation voltage, a candidate's potency, a dosing quantity, an in-vivo selectivity, or a clinical effect. Those magnitudes are [O] open.

Source

Guindon 2008 Br J Pharmacol 153:319 (CB2 analgesia) · reproduce the read (engine)

See also: its lever · prioritisation · grading.