OPRK1 — kappa-opioid receptor

OPRK1 (kappa-opioid receptor) is a lever-context non-opioid analgesic target. Its promoter reads γ = 1.4351, placing it on the firing-threshold scale at |h_sp| = 0.661716; the intervention direction is to comparator: peripheral kappa — a non-reward analgesia direction. The read is reproducible [V]; the clinical magnitude is open [O].

OPRK1 is read from its human promoter by the same deterministic engine used across the map (nearest-neighbour stacking energy → γ = 1.4351; R19 scale → |h_sp| = 0.661716). The read places the gene in lever context; its selectivity is cited Layer-2 biology, and every clinical magnitude (potency, dose, efficacy, safety) is graded [O].

The read

OPRK1 — kappa-opioid receptor sits in the threshold map at γ = 1.4351, |h_sp| = 0.661716 (barrier 0.514878). It belongs to lever context; the intervention direction is to comparator: peripheral kappa — a non-reward analgesia direction (dysphoria caveat).

selectivity (cited) peripheral kappa (centrally-restricted dysphoria caveat)

burden (comparator)

Grades

• read [V] reproducible promoter-switch-threshold read
• order [F] forced by reads
• lever [O] comparator only: read for contrast; NOT a recommended target
• mechanism [O] comparator only: read for contrast; NOT a recommended target
• clinical magnitude [O] OPEN — not a voltage, potency, dose, selectivity-in-vivo, or effect

Firewall. γ here is a read of promoter switch-threshold structure only — never this channel's activation voltage, a candidate's potency, a dosing quantity, an in-vivo selectivity, or a clinical effect. Those magnitudes are [O] open.

Source

Stein 2013 Nat Med 19:1448 (peripheral opioid analgesia) · reproduce the read (engine)

See also: its lever · prioritisation · grading.