OPRM1 — mu-opioid receptor

OPRM1 (mu-opioid receptor) is a lever-context non-opioid analgesic target. Its promoter reads γ = 1.2548, placing it on the firing-threshold scale at |h_sp| = 0.541016; the intervention direction is to comparator: mu-opioid — the REWARD-engaging axis the logic routes AWAY from. The read is reproducible [V]; the clinical magnitude is open [O].

OPRM1 is read from its human promoter by the same deterministic engine used across the map (nearest-neighbour stacking energy → γ = 1.2548; R19 scale → |h_sp| = 0.541016). The read places the gene in lever context; its selectivity is cited Layer-2 biology, and every clinical magnitude (potency, dose, efficacy, safety) is graded [O].

The read

OPRM1 — mu-opioid receptor sits in the threshold map at γ = 1.2548, |h_sp| = 0.541016 (barrier 0.393631). It belongs to lever context; the intervention direction is to comparator: mu-opioid — the REWARD-engaging axis the logic routes AWAY from.

selectivity (cited) central reward + analgesia (addiction/respiratory liability)

burden (comparator only — not a recommended target)

Grades

• read [V] reproducible promoter-switch-threshold read
• order [F] forced by reads
• lever [O] comparator only: read for contrast; NOT a recommended target
• mechanism [O] comparator only: read for contrast; NOT a recommended target
• clinical magnitude [O] OPEN — not a voltage, potency, dose, selectivity-in-vivo, or effect

Firewall. γ here is a read of promoter switch-threshold structure only — never this channel's activation voltage, a candidate's potency, a dosing quantity, an in-vivo selectivity, or a clinical effect. Those magnitudes are [O] open.

Source

Matthes 1996 Nature 383:819 (mu-receptor mediates morphine reward + analgesia) · reproduce the read (engine)

See also: its lever · prioritisation · grading.