SCN9A — Na_V1.7

SCN9A (NaV1.7) is a lever-L1 non-opioid analgesic target. Its promoter reads γ = 1.4014, placing it on the firing-threshold scale at |h_sp| = 0.638545; the intervention direction is to reduce inward Na⁺. The read is reproducible [V]; the clinical magnitude is open [O].

SCN9A is read from its human promoter by the same deterministic engine used across the map (nearest-neighbour stacking energy → γ = 1.4014; R19 scale → |h_sp| = 0.638545). The read places the gene in lever L1; its selectivity is cited Layer-2 biology, and every clinical magnitude (potency, dose, efficacy, safety) is graded [O].

The read

SCN9A — Na_V1.7 sits in the threshold map at γ = 1.4014, |h_sp| = 0.638545 (barrier 0.49098). It belongs to lever L1; the intervention direction is to reduce inward Na⁺ (raise AP threshold at the firing gate).

selectivity (cited) nociceptor-enriched (peripheral; +sympathetic/olfactory)

burden Tier-1 neuropathic + Tier-3 channelopathy

Grades

• read [V] reproducible promoter-switch-threshold read
• order [F] forced by reads
• lever [F] structural lever + direction (anchored to cited agents)
• mechanism [F] structural: peripheral current block raises the firing threshold (anchored to cited agents)
• clinical magnitude [O] OPEN — not a voltage, potency, dose, selectivity-in-vivo, or effect

Firewall. γ here is a read of promoter switch-threshold structure only — never this channel's activation voltage, a candidate's potency, a dosing quantity, an in-vivo selectivity, or a clinical effect. Those magnitudes are [O] open.

Source

Cox 2006 Nature 444:894 (LOF->CIP); Drenth 2005 / Estacion 2008 (GOF->IEM/PEPD) · reproduce the read (engine)

See also: its lever · prioritisation · grading.