Circulatory Transport and Clearance: Hemodynamics, Renal Filtration, and Hepatic Clearance from the Jamming Substrate

The kidney, liver and circulation are built as one pressure-flow and clearance network from one premise — the vacuum as a jammed medium. The organs are not assumed: they emerge from measured human master-gene DNA (SIX2, HHEX stacking energy γ), and hemodynamics, renal filtration, osmoregulation, hepatic clearance, fourteen disease states and a carcinogenesis kernel follow deterministically.

This volume is derived from VP Theory (jamming branch). The shared R19 switch and γ are common to the DNA and neural volumes.

1. §1 Organ emergence from measured γ [V]
2. §2 Arterial pressure: MAP = CO × SVR [F]
3. §3 Windkessel diastolic decay τ = R × C [F]
4. §4 Glomerular filtration and autoregulation plateau [V]
5. §5 Osmoregulation and the ADH thirst loop [V]
6. §6 Hepatic clearance and oral bioavailability [F]
7. §7 Carcinogenesis as R19 barrier lowering [F]
8. §8 Renal cell carcinoma and the smoking dose response [V]
9. §9 Hepatocellular carcinoma and aflatoxin HBV synergy [V]
10. §10 Arterial stiffening and isolated systolic hypertension [V]
11. §11 Essential hypertension as a resistance rise [F]
12. §12 Hypotension and shock subtypes [F]
13. §13 Diabetes insipidus and the failed osmostat [V]
14. §14 SIADH as an inappropriately low osmostat [V]
15. §15 Chronic kidney disease and GFR staging [V]
16. §16 Autoregulation breakthrough and glomerular hypertension [V]
17. §17 Hepatic impairment and the dose-reduction rule [V]
18. §18 Portosystemic shunt and first-pass escape [F]
19. §19 Enzyme induction, inhibition, and drug interactions [V]
20. §20 Carcinogenesis root: the reversibility threshold [H]
21. §21 Therapeutic leverage: de-escalation and barrier restoration [H]
22. §22 Renal cancer: the carcinogen roster and prevention [H]
23. §23 Liver cancer: the carcinogen roster, synergy, and prevention [H]

Every claim carries an honest grade [F] forced / [V] simulation-verified / [L] literature-anchored / [O] open, and a deterministic reproduction path. All 23 discriminant targets pass; two independent runs give the byte-identical result digest d8610156dcddf17e. Reproduction code (stdlib-only, offline): https://github.com/rego093-sketch/jamming-physics.