Diseases — A

83 diseases in this group. Each links to a full page: the emergence switch, the forced corrective direction, mapped agents, and the firewall. Direction only — no dose.

• Aromatic L-amino acid decarboxylaseMATCH · ↓ DOWN · restore by supplyDDC
• ABCA3 deficiency / surfactant metabolism dysfunction 3 OMIM…HOLD · ↓ DOWN · restore by supplyABCA3
• AbetalipoproteinemiaMATCH · ↓ DOWN · restore by supplyMTTP
• AceruloplasminemiaMATCH · ↑ UP · restore by clearCP
• Triple A / Allgrove syndromeMATCH · ↓ DOWN · restore by supplyAAAS
• Achondroplasia OMIM 100800MATCH · ↓ DOWN · restore by clearFGFR3
• AchromatopsiaHOLD · ↓ DOWN · restore by supplyCNGA3
• AchromatopsiaHOLD · ↓ DOWN · restore by supplyCNGB3
• Peroxisomal acyl-CoA oxidase 1 deficiencyHOLD · ↓ DOWN · restore by supplyACOX1
• Acrodermatitis enteropathicaMATCH · ↓ DOWN · restore by supplySLC39A4
• Acrodysostosis 1 with hormone resistanceHOLD · ↑ UP · restore by clearPRKAR1A
• Acromesomelic dysplasia, Maroteaux typeHOLD · ↓ DOWN · restore by supplyNPR2
• ACTA1-related congenital myopathyHOLD · ↓ DOWN · restore by supplyACTA1
• Acute intermittent porphyria OMIM 176000MATCH · ↑ UP · restore by clearHMBS
• AD hyper-IgEHOLD · ↓ DOWN · restore by supplySTAT3
• Adenine phosphoribosyltransferase deficiencyMATCH · ↑ UP · restore by clearAPRT
• Adenosine deaminase deficiencyMATCH · ↓ DOWN · restore by supplyADA
• POGZ neurodevelopmental disorderHOLD · ↓ DOWN · restore by supplyPOGZ
• ADNP syndrome OMIM 615873HOLD · ↓ DOWN · restore by supplyADNP
• ADPKDMATCH · ↑ UP · restore by clearPKD2
• Adenylosuccinate lyase deficiencyHOLD · ↓ DOWN · restore by supplyADSL
• Adult polyglucosan body diseaseHOLD · ↓ DOWN · restore by supplyGBE1
• Congenital afibrinogenemiaMATCH · ↓ DOWN · restore by supplyFGA
• Arginine:glycine amidinotransferaseMATCH · ↓ DOWN · restore by supplyGATM
• Aicardi-Goutieres syndrome 5MATCH · ↑ UP · restore by clearSAMHD1
• Aicardi-Goutieres syndrome 2MATCH · ↑ UP · restore by clearRNASEH2B
• Aicardi-Goutieres syndrome 1MATCH · ↑ UP · restore by clearTREX1
• Adenylate kinase 1 deficiencyHOLD · ↓ DOWN · restore by supplyAK1
• Alagille syndromeMATCH · ↑ UP · restore by clearJAG1
• Aldolase A deficiencyHOLD · ↓ DOWN · restore by supplyALDOA
• Alexander diseaseHOLD · ↑ UP · restore by clearGFAP
• ALG1-CDGHOLD · ↓ DOWN · restore by supplyALG1
• ALG3-CDGHOLD · ↓ DOWN · restore by supplyALG3
• ALG6-CDGHOLD · ↓ DOWN · restore by supplyALG6
• ALG8-CDGHOLD · ↓ DOWN · restore by supplyALG8
• AlkaptonuriaMATCH · ↑ UP · restore by clearHGD
• Allan-Herndon-Dudley syndromeHOLD · ↓ DOWN · restore by supplySLC16A2
• Alpers-Huttenlocher syndromeHOLD · ↓ DOWN · restore by supplyPOLG
• Alpha-1-antitrypsin deficiency OMIM 613490MATCH · ↓ DOWN · restore by supplySERPINA1
• Alpha-mannosidosisMATCH · ↓ DOWN · restore by supplyMAN2B1
• Alport autosomalMATCH · ↑ UP · restore by clearCOL4A3
• Alport autosomalMATCH · ↑ UP · restore by clearCOL4A4
• Alport syndrome X-linkedMATCH · ↑ UP · restore by clearCOL4A5
• Autoimmune lymphoproliferative syndromeMATCH · ↑ UP · restore by clearFAS
• Alstrom syndromeHOLD · ↑ UP · restore by clearALMS1
• Alternating hemiplegia of childhoodMATCH · ↑ UP · restore by clearATP1A3
• Alpha-methylacyl-CoA racemase deficiencyHOLD · ↑ UP · restore by clearAMACR
• Andersen-Tawil syndromeMATCH · ↓ DOWN · restore by clearKCNJ2
• Androgen insensitivityMATCH · ↓ DOWN · restore by supplyAR
• AniridiaHOLD · ↓ DOWN · restore by supplyPAX6
• KBG syndromeHOLD · ↓ DOWN · restore by supplyANKRD11
• Anophthalmia/microphthalmiaHOLD · ↓ DOWN · restore by supplyOTX2
• Antley-Bixler syndrome with disordered steroidogenesisHOLD · ↓ DOWN · restore by supplyPOR
• Ataxia with oculomotor apraxia type 1HOLD · ↓ DOWN · restore by supplyAPTX
• Ataxia with oculomotor apraxia type 2HOLD · ↓ DOWN · restore by supplySETX
• APECED / APS-1HOLD · ↑ UP · restore by clearAIRE
• Apert syndromeNOVEL · ↑ UP · restore by clearFGFR2
• Apparent mineralocorticoid excessMATCH · ↑ UP · restore by clearHSD11B2
• DOCK8 deficiency / autosomal recessive hyper-IgE syndrome…MATCH · ↓ DOWN · restore by supplyDOCK8
• Argininemia / arginase-1 deficiencyMATCH · ↑ UP · restore by clearARG1
• Argininosuccinic aciduriaMATCH · ↑ UP · restore by clearASL
• Coffin-Siris syndromeHOLD · ↓ DOWN · restore by supplyARID1A
• Aromatase deficiencyMATCH · ↓ DOWN · restore by supplyCYP19A1
• ARPKDHOLD · ↑ UP · restore by clearPKHD1
• ARSACS OMIM 270550HOLD · ↓ DOWN · restore by supplySACS
• Artemis-deficient severe combined immunodeficiencyMATCH · ↓ DOWN · restore by supplyDCLRE1C
• Arts syndromeHOLD · ↓ DOWN · restore by supplyPRPS1
• ARVCMATCH · ↑ UP · restore by clearDSG2
• ARVCMATCH · ↑ UP · restore by clearDSP
• Arrhythmogenic RV cardiomyopathyMATCH · ↑ UP · restore by clearPKP2
• Asparagine synthetase deficiencyHOLD · ↓ DOWN · restore by supplyASNS
• AspartylglucosaminuriaHOLD · ↓ DOWN · restore by supplyAGA
• Ataxia-telangiectasiaHOLD · ↑ UP · restore by clearATM
• ATR-X syndromeHOLD · ↓ DOWN · restore by supplyATRX
• Congenital atransferrinemiaHOLD · ↓ DOWN · restore by supplyTF
• Arterial tortuosity syndromeHOLD · ↓ DOWN · restore by supplySLC2A10
• Atypical haemolytic uraemic syndromeMATCH · ↑ UP · restore by clearCFH
• Auditory neuropathyHOLD · ↓ DOWN · restore by supplyOTOF
• Autosomal dominant hypocalcaemia type 1MATCH · ↓ DOWN · restore by supplyCASR
• Autosomal dominant polycystic kidney disease, type 1MATCH · ↑ UP · restore by clearPKD1
• Autosomal recessive cerebellar ataxia 1HOLD · ↓ DOWN · restore by supplySYNE1
• AUTS2 syndromeHOLD · ↓ DOWN · restore by supplyAUTS2
• Axenfeld-Rieger syndromeMATCH · ↑ UP · restore by clearFOXC1