§6 · the measured atlas
The canonical reprogramming escapees rank exactly by barrier
On the measured 12-locus imprinted atlas, survival across the two erasures ranks ascending-γ exactly (ρ = 1.00): KCNQ1OT1 inherits best (γ = 1.5637), SNRPN worst (γ = 1.2794). The harsher of the two erasures dominates the compound, and a measured critical re-write rate separates maintained from transient inheritance. [V].
The framework predicts that only deep-barrier loci cross both erasures; the imprinted atlas is the natural test set, and survival is monotone in γ with Spearman ρ = 1.00 across 12 loci. The critical re-write rate is w* = 0.0271.
A pre-declared test set
The imprinted and metastable-epiallele loci are exactly the genome's known reprogramming escapees, so they are the honest panel for the barrier prediction. Measured through the identical SOX9-gated pipeline, their survival ranks ascending-γ with a perfect Spearman ρ = 1.00.
| locus | γ | parent-of-origin | p(survive) |
|---|---|---|---|
| SNRPN | 1.2794 | paternal | 0.6400 |
| MEST | 1.3645 | paternal | 0.6835 |
| PEG3 | 1.3961 | paternal | 0.6960 |
| PLAGL1 | 1.4122 | paternal | 0.7020 |
| GNAS | 1.4256 | complex | 0.7090 |
| IGF2 | 1.4372 | paternal | 0.7137 |
| GRB10 | 1.4839 | complex | 0.7410 |
| NNAT | 1.4853 | paternal | 0.7418 |
| H19 | 1.4881 | maternal | 0.7430 |
| MEG3 | 1.5131 | maternal | 0.7568 |
| DLK1 | 1.5482 | paternal | 0.7730 |
| KCNQ1OT1 | 1.5637 | paternal | 0.7815 |
The two erasures resolved — the harsher dominates
Splitting the single noise pulse into a PGC window (D = 0.20) and a harsher zygotic window (D = 0.28), the compound is set by the harsher one. A deep escapee (γ = 1.5637) still beats a shallow locus across both windows; survival compounds 0.556 vs 0.3777.
A boundary between maintained and transient
With a measured per-generation loss of 0.2708, there is a critical re-write rate w* = 0.0271: a persistent environment that re-loads the payload above w* holds the effect indefinitely, while a transient exposure below it fades to zero. The boundary is the substrate's line between an inherited habit and a passing one; its calendar value in the wild is [O].