§6 · the measured atlas

The canonical reprogramming escapees rank exactly by barrier

On the measured 12-locus imprinted atlas, survival across the two erasures ranks ascending-γ exactly (ρ = 1.00): KCNQ1OT1 inherits best (γ = 1.5637), SNRPN worst (γ = 1.2794). The harsher of the two erasures dominates the compound, and a measured critical re-write rate separates maintained from transient inheritance. [V].

The framework predicts that only deep-barrier loci cross both erasures; the imprinted atlas is the natural test set, and survival is monotone in γ with Spearman ρ = 1.00 across 12 loci. The critical re-write rate is w* = 0.0271.

A pre-declared test set

The imprinted and metastable-epiallele loci are exactly the genome's known reprogramming escapees, so they are the honest panel for the barrier prediction. Measured through the identical SOX9-gated pipeline, their survival ranks ascending-γ with a perfect Spearman ρ = 1.00.

GE1 — imprinted survival ranks ascending-γ (D = 0.22, 12 loci)
locusγparent-of-originp(survive)
SNRPN1.2794paternal0.6400
MEST1.3645paternal0.6835
PEG31.3961paternal0.6960
PLAGL11.4122paternal0.7020
GNAS1.4256complex0.7090
IGF21.4372paternal0.7137
GRB101.4839complex0.7410
NNAT1.4853paternal0.7418
H191.4881maternal0.7430
MEG31.5131maternal0.7568
DLK11.5482paternal0.7730
KCNQ1OT11.5637paternal0.7815

The two erasures resolved — the harsher dominates

Splitting the single noise pulse into a PGC window (D = 0.20) and a harsher zygotic window (D = 0.28), the compound is set by the harsher one. A deep escapee (γ = 1.5637) still beats a shallow locus across both windows; survival compounds 0.556 vs 0.3777.

A boundary between maintained and transient

With a measured per-generation loss of 0.2708, there is a critical re-write rate w* = 0.0271: a persistent environment that re-loads the payload above w* holds the effect indefinitely, while a transient exposure below it fades to zero. The boundary is the substrate's line between an inherited habit and a passing one; its calendar value in the wild is [O].

FIREWALL · The survival ORDERING, the harsher-erasure dominance, and the re-writing BOUNDARY are read; absolute penetrance and the wild generation index are [O]. Every clinical application — vaccination, gene therapy, fertility care — is handed to clinicians and regulators. see the [O] ledger →