§11 · application: therapy

Two therapeutic levers: edit the SET, or reset the drive

Two levers. Lever A edits the SET — a γ-edit relocates the spinodal (0.6363→0.6917) and the barrier (0.4887→0.5462), and is not reversible by a drive. Lever B resets the drive reversibly via RNA, γ untouched. The lever choice is a geometry threshold: drive-reachable → B; beyond a tolerable cap → A. [V].

A γ-edit from 1.3981 to 1.4781 permanently relocates the threshold; an RNA reset on TARBP2 (γ = 1.5122) forces OFF and reverses on withdrawal. The decision rule separates the two by whether a tolerable drive can clear the pathological hold.

Lever A — edit the SET (irreversible by a drive)

A base/prime edit changes γ itself, relocating the spinodal and barrier for good. From 1.3981 to 1.4781 the threshold moves and no drive can put it back — the SET is the unwritable channel, so editing it is permanent.

Lever B — reset the drive (reversible)

An siRNA forces a target switch OFF and releases it on withdrawal, with γ untouched (worked on TARBP2, γ = 1.5122). This is the reversible, tunable lever — the therapeutic face of the RNA writable channel.

The decision is geometry

On PAX5 (γ = 1.4892, spinodal 0.6995) with a tolerable-drive cap of 1.7487, a shallow pathological tilt is cleared by a tolerable drive (use Lever B), while a deep pathological hold exceeds the cap and demands a SET edit (Lever A). The rule is a threshold in the geometry; the cap's absolute value is [O].