Methods, grades, and reproducibility

Every quantity here is reproduced deterministically from the R19 jamming-lattice substrate and measured master-gene γ; two runs give an identical SHA-256. Master-gene γ values are measured inputs (cited from the DNA gene-clock), never fitted; dynamical scales are dimensionless and graded honestly — shape [V], cited anchors [L], absolute magnitudes [O] with stated obstacles.

All results derive from the R19 bistable substrate and measured master-gene γ under a strict no-tuning rule. The pipeline is bit-reproducible to an identical SHA-256, and every claim is graded, with each open item carrying a stated obstacle.

Substrate and discipline

Every result here is reproduced from one vendored primitive: the R19 bistable switch ds/dt = g·s − s³ + h, with its spinodal, barrier, and dwell. The only organism-specific inputs are the four measured master-gene γ values, carried read-only from the DNA gene-clock package.

The governing rule is the no-tuning invariant: every constant is either a measured input (cited and locked) or substrate-derived — never chosen to fit a target. The measured γ drive falsifiable cross-checks (the developmental order, the γ1.5 insult ordering, the equal-dwell turnover); the dimensionless dynamical scales set the regime in which each mechanism is exhibited and are graded honestly rather than calibrated to data.

Grades

GradeMeaning
[F] Forced (substrate)Forced by the substrate (e.g. a spinodal computed from measured γ).
[V] Simulation-verifiedSimulation-verified shape, control, or ordering.
[L]Cited external anchor (a measured number from the literature).
[O] Open (obstacle stated)Open, with the obstacle to closing it stated explicitly.

Reproducibility

The research pipeline is deterministic: BLAS is pinned single-thread, all grids are fixed, and no random number generator is used. Two independent runs produce a byte-identical result, hashed to SHA-256 1fb59f556e01882916c0f4b4e72aa76ad47ef348bffb81fe4a7f3ce9093d3e92. The writing phase is gated — this site cannot be generated until the research gate is green and the phase is flipped.

To reproduce: run python repro/run_all.py for the full research record, python repro/_verify/stress_tests.py for the graded stress battery (targets T1–T5 plus the carcinogenesis dichotomy), and python repro/_verify/gates.py for the determinism and gate check. The engine code is bundled in this package under repro/ and is the canonical source for every number above.

Open items (obstacle ledger)

The following are the absolute quantities this package does not yet derive, each with its obstacle: absolute TEWL (lipid permeability + water-activity gradient); absolute wound closure rate (single-cell migration speed); absolute minimal erythema dose (melanin extinction coefficient); absolute basal cycle time (per-cell calibration); absolute set-point and sweat rate (per-gland output + body heat capacity); absolute cancer incidence and relative-risk magnitude (population baseline rate + absolute dose calibration). The shapes, controls, orderings, and dichotomies above stand independently of these [O] Open (obstacle stated) items.