Frequently asked questions
What is the one substrate the whole chain stands on?
The R19 bistable switch (ds/dt = g s − s³ + h), the jamming-lattice primitive that also writes DNA genes. A neuron is that switch plus a slow FitzHugh–Nagumo recovery — a low-frequency relaxation oscillator. Every cell in this volume runs the same switch; only the inherited measured γ changes.
What is the strongest result?
Working-memory capacity equals the θ/γ ratio, about 7±2, because each gamma cycle nested in one theta cycle holds one item. It is the one link with causal validation: manipulating theta with tACS changes the realised capacity in the predicted direction (§4).
What is the inherited analgesic map (§21)?
From the sibling whitepaper analgesic_threshold_logic v2.0 (DOI 10.5281/zenodo.20733420): 27 non-opioid analgesic targets placed on the firing-threshold scale |h_sp| = spinodal(γ), re-derived on this volume\u2019s own byte-identical engine (drift 0) and sorted into three drug-class levers — reduce the inward current (L1), open K_V7 (L2), remove the NGF/CGRP drive (L3). Each raises the nociceptor firing threshold. See §21.
Which pain conditions does this volume own?
Acquired, dynamics-key conditions read on the nociceptor firing threshold — neuropathic pain, sensitisation, inflammatory/nociplastic pain (§22). Monogenic pain channelopathies (inherited erythromelalgia, PEPD, CIP/CIPA) are gene-key entities owned by the rare-disease volume (disease_wp) and only cross-referenced (§23).
What does the model NOT claim?
γ reads promoter switch-threshold STRUCTURE only — never a channel activation voltage, a drug potency, a dose, an in-vivo selectivity, or a clinical effect (all [O] with stated obstacles). The felt/affective pain is the Felt Cognition volume\u2019s. No molecule is designed and nothing diagnoses, treats, or prescribes.
How is everything graded?
[V] simulation-verified · [F] forced by the locked R19 forms · [L] measured anchor · [O] open (with a stated obstacle). Simulations are deterministic (seed-fixed, 2×sha256) and the displayed numbers are regenerated by code with drift 0. See Methods.