KCNQ2 — K_V7.2

KCNQ2 (KV7.2) is a lever-L2 non-opioid analgesic target. Its promoter reads γ = 1.5768, placing it on the firing-threshold scale at |h_sp| = 0.762102; the intervention direction is to INCREASE outward K⁺. The read is reproducible [V]; the clinical magnitude is open [O].

KCNQ2 is read from its human promoter by the same deterministic engine used across the map (nearest-neighbour stacking energy → γ = 1.5768; R19 scale → |h_sp| = 0.762102). The read places the gene in lever L2; its selectivity is cited Layer-2 biology, and every clinical magnitude (potency, dose, efficacy, safety) is graded [O].

The read

KCNQ2 — K_V7.2 sits in the threshold map at γ = 1.5768, |h_sp| = 0.762102 (barrier 0.621575). It belongs to lever L2; the intervention direction is to INCREASE outward K⁺ (open K_V7.2; hyperpolarise away from threshold).

selectivity (cited) M-current; retigabine/flupirtine template (clinical caveats on those molecules)

burden Tier-1 neuropathic (excitability)

Grades

• read [V] reproducible promoter-switch-threshold read
• order [F] forced by reads
• lever [F] structural lever + direction (anchored to cited agents)
• mechanism [F] structural: open K_V7 -> hyperpolarise -> raise threshold (anchored to retigabine/flupirtine template)
• clinical magnitude [O] OPEN — not a voltage, potency, dose, selectivity-in-vivo, or effect

Firewall. γ here is a read of promoter switch-threshold structure only — never this channel's activation voltage, a candidate's potency, a dosing quantity, an in-vivo selectivity, or a clinical effect. Those magnitudes are [O] open.

Source

Wang 1998 Science 282:1890; Brown 2009 J Physiol 587:1815 (M-current) · reproduce the read (engine)

See also: its lever · prioritisation · grading.