OPRD1 — delta-opioid receptor
OPRD1 (delta-opioid receptor) is a lever-context non-opioid analgesic target. Its promoter reads γ = 1.476, placing it on the firing-threshold scale at |hsp| = 0.690204; the intervention direction is to comparator: delta-opioid. The read is reproducible [V]; the clinical magnitude is open [O].
OPRD1 is read from its human promoter by the same deterministic engine used across the map (nearest-neighbour stacking energy → γ = 1.476; R19 scale → |hsp| = 0.690204). The read places the gene in lever context; its selectivity is cited Layer-2 biology, and every clinical magnitude (potency, dose, efficacy, safety) is graded [O].
The read
OPRD1 — delta-opioid receptor sits in the threshold map at γ = 1.476, |hsp| = 0.690204 (barrier 0.544644). It belongs to lever context; the intervention direction is to comparator: delta-opioid.
selectivity (cited) peripheral/central delta
burden (comparator)
Grades
- read [V] reproducible promoter-switch-threshold read
- order [F] forced by reads
- lever [O] comparator only: read for contrast; NOT a recommended target
- mechanism [O] comparator only: read for contrast; NOT a recommended target
- clinical magnitude [O] OPEN — not a voltage, potency, dose, selectivity-in-vivo, or effect
Firewall. γ here is a read of promoter switch-threshold structure only — never this channel's activation voltage, a candidate's potency, a dosing quantity, an in-vivo selectivity, or a clinical effect. Those magnitudes are [O] open.
Source
Gaveriaux-Ruff 2011 Br J Pharmacol 163:1117 · reproduce the read (engine)
See also: its lever · prioritisation · grading.