KCNQ5 — K_V7.5

KCNQ5 (KV7.5) is a lever-L2 non-opioid analgesic target. Its promoter reads γ = 1.5307, placing it on the firing-threshold scale at |h_sp| = 0.728926; the intervention direction is to INCREASE outward K⁺. The read is reproducible [V]; the clinical magnitude is open [O].

KCNQ5 is read from its human promoter by the same deterministic engine used across the map (nearest-neighbour stacking energy → γ = 1.5307; R19 scale → |h_sp| = 0.728926). The read places the gene in lever L2; its selectivity is cited Layer-2 biology, and every clinical magnitude (potency, dose, efficacy, safety) is graded [O].

The read

KCNQ5 — K_V7.5 sits in the threshold map at γ = 1.5307, |h_sp| = 0.728926 (barrier 0.585761). It belongs to lever L2; the intervention direction is to INCREASE outward K⁺ (open K_V7.5; hyperpolarise away from threshold).

selectivity (cited) DRG/peripheral M-current component

burden Tier-1 neuropathic (excitability)

Grades

• read [V] reproducible promoter-switch-threshold read
• order [F] forced by reads
• lever [F] structural lever + direction (anchored to cited agents)
• mechanism [F] structural: open K_V7 -> hyperpolarise -> raise threshold (anchored to retigabine/flupirtine template)
• clinical magnitude [O] OPEN — not a voltage, potency, dose, selectivity-in-vivo, or effect

Firewall. γ here is a read of promoter switch-threshold structure only — never this channel's activation voltage, a candidate's potency, a dosing quantity, an in-vivo selectivity, or a clinical effect. Those magnitudes are [O] open.

Source

Lerche 2000 J Biol Chem 275:22395; Tzingounis 2010 PNAS 107:10232 · reproduce the read (engine)

See also: its lever · prioritisation · grading.