Claims ledger
This page lists every headline and central claim of the 32 volumes. Each claim is classed by what the evidence in this repository actually shows, not by the grade printed on its page. Internal coherence is not evidence. The claims that can decide the framework are the independent predictions and the discriminating tests. Generated from registry/claims_ledger.json (187 rows, built 2026-09-29).
Classes
| class | rows | meaning |
|---|---|---|
| independent-prediction | 16 | computed by repo code from inputs that do not contain the compared value, then compared with an external observation |
| anchor-restatement | 47 | the output equals, or is set by, an input, anchor or calibration chosen from the compared value |
| identity | 46 | holds by algebra or by construction |
| interpretation | 46 | a mapping of observed facts onto VP, with no numeric test |
| open | 32 | stated [O], or no code or data in the repository reproduces it |
Discriminating tests (4)
These are tests where VP and standard science predict different outcomes and the test can be run. None has been run on data yet.
| volume | claim | test |
|---|---|---|
| cosmology | HEADLINE: MOND-scale acceleration a0 = c H0 / 2 pi | Gaia DR3 wide binaries: Newtonian gravity predicts no velocity boost at any separation; the volume's law predicts a boost for g_N < a0 (repo WB1, pre-registered, not run: H_int boost 1.29 at 10 kAU, 1.64 at 20 kAU; H_ext bound about 1.10-1.14). Published analyses disagree: Chae 2023 reports a MOND-like boost, Banik et al. 2024 find Newtonian behaviour. |
| cosmology | Supernova Hubble diagram d_L = (c/H0)(1+z) ln(1+z) 'statistically degenerate with LambdaCDM' | Full STAT+SYS covariance fit of Pantheon+ (and other SN compilations): VP and LambdaCDM distance laws differ by about 0.2 mag at z > 1. With diagonal errors the existing test already favours LambdaCDM. |
| cosmology | Equivalence principle as a theorem (Ch3) | Composition-dependence (Q/M) test at MICROSCOPE level: GR predicts eta = 0; the volume's stated annihilation-rate source (nu_p = 3 pi^4, nu_e = 1) implies eta far above the bound. Per the review this is not pending: existing MICROSCOPE data already conflict. |
| chemistry | Black copper (CuO nanocoat) converts infrared into directed current (VP chi-conversion: transverse chi≈90 deg -> conduction chi->0) | BC4 bench test: at matched front/back temperatures standard physics predicts ΔV = 0 (sub-µV systematics bound 0.2 µV, threshold 3 µV); VP chi-conversion predicts ΔV ≠ 0 that reverses sign when the plate is flipped, with an uncoated control at 0. |
VP Theory
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: c^2 = B/rho is the speed of light (the lattice's one surviving elastic wave is light) | interpretation | no numeric test of the identification itself | docs/physics/lt-light-chain-doubts-and-resolutions/index.html (graded table: identification [H]); reviews/physics/2026-09-28_review_report.md §2-③ |
| At the isostatic point G_relaxed -> 0 while B stays finite, so one longitudinal speed survives ('five observables in 3-D') | independent-prediction | z0 within about 0.1 of 6 across five observables | docs/physics/lt-light-chain-doubts-and-resolutions/index.html (Link 2); repro/physics/bundle_v0.4/02_lattice_percolation_soc/jamming_spine_verification_v0.4_2026-06-05/01_stiffness_to_c2/, 02_shear_relaxedG/ |
| Test E2: the wavelength-free lattice number A links a measured light wavelength (I2-HeNe 632.991 nm) to the electron scale D = 2 lambda_C,e | independent-prediction | A_req/median = 1.052 (pull 0.51 half-widths); D +5.2%; lambda -5.0%; resolving power about ±10% | repro/physics/experiments/E2/RESULT.json, README.md, PREREG.json (committed 235a911 before analysis), e2_link_test.py |
| Proton-electron mass ratio m_p/m_e = 6 pi^5 (graded [F] via LOCK-NU-N) | anchor-restatement | -18.8 ppm; as an exact identity about -1.08e6 sigma from CODATA 2022; no theory-error budget is registered | repro/physics/experiments/LEE/lee_6pi5.py; repro/physics/site_seed/sections_map.csv row 8.0.5 (LOCK-NU-N inputs: delta, n=3, N-1 lemma); docs/physics/mr-mass-ratio-chain-6pi5-step-by-step/index.html; reviews/physics/2026-09-28_review_report.md §2-①② |
| Proton radius r_p = D/(6 pi^6) (reclassified from locked input to prediction) | anchor-restatement | +0.78 sigma (+0.06%) | repro/physics/verification_dossier/DOUBT_REMOVAL_MAP.md line 20; repro/physics/site_seed/sections_map.csv row 8.0.5; reviews/physics/2026-09-28_review_report.md §2-⑤ |
| Higgs mass m_H = h c N / (5 pi lambda_ref) | anchor-restatement | -0.40% (-4.6 sigma) | reviews/physics/2026-09-28_review_report.md §2-④ |
| 1/alpha ≈ 137 from the hydrogen stand-off a0/(D/4pi) (the '137 bridge') | identity | circular: identity to 7e-11; the 1e-5 residual is rounding plus reduced-mass terms | repro/physics/experiments/EL1_electron_standard_x_vp/RESULT.json (P3); EL2_alpha_from_stiff_zone/RESULT.json; EL3_why_137_appeared/RESULT.json + README.md; EL4_equal_size_shells/RESULT.json |
Configured Continuum
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: balance laws from the arrangement; Newtonian closure sigma = -pI + 2 eta D below the jamming margin | interpretation | P1-P3 PASS; P4 (two eta routes) FAIL as registered, post-hoc ratio 0.96 in linear regime | repro/fluid-dynamics/experiments/NC1_newtonian_closure/README.md, RESULT.json, PREREG.json; reviews/fluid-dynamics/2026-09-29_reviewer2_code_data.md F-13 |
| Three-sphere C3 -> one-axis through-flow; closed in 3-D, 82 = 81 + 1 carries over to fluids | open | C3E1: D_sys = 0.118 vs noise 0.133; 81-core lobe D proportional to epsilon (no amplification) | repro/fluid-dynamics/experiments/C3E1_three_sphere_directed_ejection/README.md (P1-P3, P5, P6 FAIL); in-volume support: corotation.py, rigid_shell.py, lattice_inflow.py (review F-11: lattice_inflow prints PASSES unconditionally) |
| Navier-Stokes global regularity 'recast' / rearrangement events as a regularization valve | open | no blow-up diagnostic in any script | reviews/fluid-dynamics/2026-09-29_reviewer2_code_data.md F-01; repro/fluid-dynamics/IRREPRODUCIBILITY_LEDGER.md G1 |
| Onsager-type dissipation anomaly: eps saturates at about 0.2 as nu -> 0 (Pillar IV) | identity | shipped stochastic run budget residual 0.333 (vs stated 'closes within 2%') | metriplectic_vortex.py (review F-04); repro/fluid-dynamics/experiments/ONS1_adg_vortex_gas/README.md |
| Transition class: five directed-percolation exponents, 'no tuning' | anchor-restatement | nu_par 5.6% off, theta_s 7% off; final run's own sum 0.4395 vs DP 0.4732 | transition_dp_final.py:97-100 (PASS printed as string literals); review F-06 |
| Avalanche exponent tau in pre-registered band [1.40, 1.50] | open | N=64 outside band; at h=2,3 the N=96 MLE is 1.713, 1.677 | avalanche_N64.out.txt ('TENSION'), avalanche_N96.out.txt; review F-07 |
| Length selection: wavenumber scales with exponent beta ≈ 1/2 (blind DNS beta = 0.501) | identity | finer run moves away from 0.5; N=512 DNS (0.501) not shipped | length_selection.py (08-…); review F-09 |
Vacuum-Inflow Cosmology
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: MOND-scale acceleration a0 = c H0 / 2 pi | anchor-restatement | about -10% (0.90x), within 0.5 sigma_sys | repro/cosmology/legacy_v2_3/ch6_galaxy_rar.py lines 8-9, 86-96 ('the coefficient is SELECTED by motivation'; data fix k only to 5-7); reviews/cosmology/2026-09-28_reviewer2_data_code.md M1; repro/cosmology/experiments/WB1_wide_binary_a0_test/ |
| Kepler / Solar-system orbits from vacuum inflow | anchor-restatement | ≤ 0.73% (Saturn +0.73% is the Jupiter-Saturn perturbation / osculating-element effect) | cos_locks.json (GM_sun = kappa Q_sun badge 'calibrated'), per reviews/cosmology/2026-09-28_reviewer2_data_code.md |
| NGC 2403 rotation curve fitted 'at the derived a0, a0 not fitted' | anchor-restatement | at derived a0 = 1.082e-10: Upsilon = 0.606, chi2/dof = 2.57; joint fit prefers a0 ≈ 1.7e-10 (chi2/dof 1.09) | repro/cosmology/legacy_v2_3/ch6_galaxy_rar.py line 33 (a0 = 1.2e-10 'empirical RAR scale (for the fit)'); reviews/cosmology/2026-09-28_reviewer2_data_code.md C2 |
| Supernova Hubble diagram d_L = (c/H0)(1+z) ln(1+z) 'statistically degenerate with LambdaCDM' | independent-prediction | Delta chi2 ≈ +87 against LambdaCDM (VP disfavoured); about +0.2 mag departure at z > 1; stated max |Delta mu| 0.145 not reproduced (0.23-0.33) | repro/cosmology/legacy_v2_3/ch7_lattice_optics.py; reviews/cosmology/2026-09-28_reviewer2_data_code.md C3; reviews/2026-09-28_cosmology_chemistry_synthesis.md |
| Gravitational waves: two tensor polarizations (+, x), no breathing mode, speed c (quanta carried on the VP scaffold) | interpretation | P1, P2, P4 PASS; P3 FAIL (heavy quanta also carried at c) | repro/cosmology/experiments/GW2_rotating_quanta_on_scaffold/README.md, RESULT.json, PREREG.json |
| Equivalence principle as a theorem (Ch3) | open | reviewer estimate from the volume's own ratios: 0.2-0.8% composition dependence, about 1e12-1e13 above the bounds | reviews/cosmology/2026-09-28_reviewer1_logic.md C1 (lines ~40-50, 226); reviews/physics/2026-09-28_review_report.md §2-⑥ |
| Light deflection 1.752 arcsec at the solar limb (index n ≈ 1 + v^2/c^2 with v = c sqrt(R_s/r)) | anchor-restatement | matches GR by construction | reviews/cosmology/2026-09-28_reviewer1_logic.md C2 and line 145/214 (Ch10: 'GR-matched index, gamma = 1' imported in Ch8) |
VP Chemistry & EM
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: EM on the jammed substrate — E = transverse swing, B = lattice rotation; chemistry from one electron picture | interpretation | no numeric test | AGENTS.md §3.3 chemistry row; reviews/2026-09-28_cosmology_chemistry_synthesis.md (chemistry: E/B old reading); reviews/chemistry/2026-09-28_reviewer1_logic.md |
| c^2 = B/rho 'reproduced to 0.06%' by a deterministic simulation (hub, §1, §2 [V]) | identity | packet-width dependent: 0.955, 0.980, 0.993, 0.998, 0.9995 for sigma = 2-20 sites | reviews/chemistry/2026-09-28_reviewer2_data_code.md F-02 (lines 13, 49-68); AGENTS.md §2 |
| Case harness: 32/32 PASS (and 6/6 PASS) over a 114-row case ledger | open | cannot be checked | reviews/chemistry/2026-09-28_reviewer2_data_code.md line 24, 46; reviews/2026-09-28_cosmology_chemistry_synthesis.md |
| §7 low-grade waste heat -> electricity (regenerator/microchannel) | open | page quotes 2.6-4.4% (mechanical) as the efficiency; thermal-to-electric is 1.35-2.27% | vp_regenerator_microchannel.py (§7, runs, hashes match); reviews/chemistry/2026-09-28_reviewer2_data_code.md line 96 |
| Black copper (CuO nanocoat) converts infrared into directed current (VP chi-conversion: transverse chi≈90 deg -> conduction chi->0) | open | BC1: no net charge current without a junction (P2, P5 FAIL for the author's hypothesis); BC2 P1: zero net power at equal T (detailed balance, identity); BC6 standard-physics rectenna 3.0-5.0% of net flux at 300-600 C | repro/chemistry/experiments/BC1_why_black_electron_tracking/, BC2_black_cu_boundary_ir_to_current/, BC4_black_cu_radiative_vs_conductive_voltage/ (PREDICTION.json, not run), BC5_black_cu_ir_rectenna/, BC6_rectenna_optimization_realistic_ess/, ESS1/, ESS2/ |
| LE1: light enters the near-longitudinal (m = 1) regime at photon energy hc/D; propagation angle sin chi = lambda/(mD) | identity | n/a | repro/chemistry/experiments/LE1_heat_vs_straight_motion_light_angle/README.md, RESULT.json, le1_run.py |
Jamming Geodynamics
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: continental break-up occurs when effective driving stress exceeds yield (Psi_eff > Psi_y) | identity | n/a | docs/geodynamics/01-one-page-overview; docs/geodynamics/16-scale-checks-omega-nogo-constraints |
| Jamming fraction reproduced from a first-principles 2-D packing simulation | independent-prediction | -0.002 | repro/geodynamics/src/geodynamics/atl_bundle/engine/jamming_microderive.py (run from scratch copy: phi_jam ~0.840; z-z_iso ~ (phi-phi_jam)^0.5, p ~ (phi-phi_jam)^1); validate_all.py 39/39 PASS |
| Friction collapse by unjamming (liquefaction, not melt) gives very low effective friction | open | model mu_eff is ~20-90x below the cited observed range; no measured mu_eff is compared at 2.2e-3 | repro/geodynamics/src/geodynamics/atl_bundle/engine/vp_jamming_friction.py; validate_all.py check C19c; docs/geodynamics/14-resistance-collapse-by-unjamming-liquefaction |
| P1: the Atlantic rim is passive-margin dominated (R_sub = L_subduction / L_perimeter) | interpretation | n/a (a threshold on an observed ratio) | repro/geodynamics/src/geodynamics/atl_bundle/engine/p1_plate_boundaries.py (rerun: 0.057) |
| Suction runaway (Lambda > 1) at continental scale | open | d_crit not directly observable | docs/geodynamics/16-scale-checks-omega-nogo-constraints; engine/c4_scalability.py, c19_master_scale.py |
| Rapid (kyr-scale / event-like) Atlantic opening and its absolute chronology | open | n/a | docs/geodynamics/20-p8-magnetic-striping-chronology-firewall; repro/geodynamics/IRREPRODUCIBILITY_LEDGER.md (Bounded HOLD items) |
| Pre-registered module verdicts P4, P16, P19, P20, P24 (PASS in r16 matrix) and P29 coherence | open | n/a | docs/geodynamics/01-one-page-overview (2026-09-29 update box): p15_*.py, *_gate.json, DataPack CSVs are pre-registration specs, not shipped code/data; only atl_bundle ships |
Cross-Chronometer Limit
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: incorporating older foreign material biases a sample's age old (radiocarbon and zircon U-Pb) | identity | n/a | docs/geochronology/03-one-contamination-mechanism-two-detectabilities; repro/geochronology/repro/geochronology/09-*/cases_catalogue.csv |
| Closure/exchange number N_D = D tau / L^2 equals the Fourier number and Dodson's closure grouping | identity | n/a | repro/geochronology/IRREPRODUCIBILITY_LEDGER.md; repro/geochronology/repro/geochronology/04-shared-physics-closure-exchange-number/README.md |
| Leave-one-out reservoir-offset correction reduces radiocarbon error out of sample | independent-prediction | residual RMSE 141 yr and 453 yr | repro/geochronology/repro/geochronology/06-demonstration-i-radiocarbon-homogeneous-case/data/*.csv (recomputed here: mean-offset LOO gives 417.5 -> 141.4 and 739.4 -> 452.5); docs/geochronology/06-* |
| Lava Creek: classifying zircon by crystal position (not age) recovers the eruption age | anchor-restatement | ~0 vs published rim age (by construction); ~-4.5 ka vs ~631 ka eruption | repro/geochronology/repro/geochronology/07-demonstration-ii-zircon-u-pb/01_lava_creek_canonical.py (assert |mr-626.5|<3) |
| General case: 204Pb common-Pb correction makes discordant grains concordant; youngest detrital grains give max depositional age | interpretation | n/a | repro/geochronology/repro/geochronology/08-demonstration-iii-zircon-u-pb/02_isoplotr_common_pb_detrital.py (clones IsoplotR; needs network) |
Continental Genesis
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: dry land exists because of composition + buoyancy (two-tier crust), not age | interpretation | n/a | docs/continental-genesis; repro/continental-genesis/BLUEPRINT_and_GRADED_LEDGER.md |
| R1: isostasy + measured ocean water volume reproduces observed freeboard with no fitted parameter | anchor-restatement | 0 m for the selected (rho_c, H_c); +333 to +1075 m for the other listed inputs | repro/continental-genesis/repro/r1_budget_screen.py (run from scratch copy): rho_c 2800/2835/2870 at 35 km -> +1915/+1544/+1173 m; 2835 at 30 km -> +840 m; ledger CG-37 |
| Bimodal hypsometry reproduced (two elevation peaks ~5.2 km apart) | identity | land peak +744..+1244 m high; ocean peak ~300-800 m shallow; separation +0.2..+0.7 km | repro/continental-genesis/repro/r1_budget_screen.py [B2] |
| Convergence is the forced downwelling limb of mantle convection | interpretation | n/a | repro/continental-genesis/BLUEPRINT_and_GRADED_LEDGER.md CG-36; repro/no_tuning_falsifier_screen.py |
| Continental area fraction is a percolation-bounded attractor | open | coupled 3-D run -0.11 (0.30 vs 0.41) | BLUEPRINT_and_GRADED_LEDGER.md CG-38/CG-39; repro/area_fraction_attractor_screen.py; simulations_session/coupled_*.py |
| Occurrence and timing of continent formation | open | n/a | docs/continental-genesis (firewall); GOVERNANCE.md |
Recent-Sequence Cascade
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: one untuned cause (release of jammed deep-water reservoir S0) closes 9 present-tense phenomena; 8:1 mechanism compression vs mainstream | interpretation | n/a | docs/recent-sequence-cascade/index.html; repro/recent-sequence-cascade/repro/m47_causal_closure_ledger.py |
| Deglaciation is recent (order 1e4 yr) because post-glacial rebound is still ongoing | anchor-restatement | n/a | repro/recent-sequence-cascade/repro/m44_deglaciation_recency_gia.py (eta = 1e21 Pa s, lambda = 3000 km, uplift 1 cm/yr) |
| Dual-redox glacial meltwater model reproduces oil quality (heavy/light, sour/sweet) across provinces | anchor-restatement | 6/6 class matches | repro/recent-sequence-cascade/repro/m42_oil_quality_model.py; repro/recent-sequence-cascade/repro/data/oil_quality_provinces.csv |
| Early-Holocene human remains are sparse in the global radiocarbon record | interpretation | n/a | repro/recent-sequence-cascade/fossil_audit/fossil_counts.py |
| Stress test vs mainstream: discriminating present-tense advantage | interpretation | n/a | repro/recent-sequence-cascade/repro/m52_tier4_mainstream_stress_test.py; reviews/earth/2026-09-29_continental_genesis_and_cascade_light_review.md |
| Occurrence of the cascade (Flood -> glaciation -> Atlantic opening) and absolute dates | open | n/a | docs/recent-sequence-cascade (bidirectional chronology firewall) |
Wave Computer
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: information is carried by oscillator phase; settling to a fixed point is the computation | interpretation | n/a | docs/wave-computer/01-wave-substrate-thesis-compute-by-phase; repro/wave-computer/repro |
| Carrier invariance: phase computation does not depend on the carrier frequency, so low-frequency thought is possible | identity | n/a | docs/wave-computer/14-inheritance-methods-provenance; repro/wave-computer/experiments/MM2_theta_locked_hippocampus/README.md (carrier drops out in the rotating frame) |
| Capability ladder: integrated L0-L8 machine clears 6/7 rungs (minimal store) and 7/7 (dual store); axioms 8 -> 5 irreducible | interpretation | n/a | docs/wave-computer/12-functional-general-intelligence-capability-ladder; docs/wave-computer/13-axiom-independence-audit-irreducible-core |
| Working-memory capacity = min(slots, phase precision) lands in the Miller range 4-9 | anchor-restatement | inside 4-9 | docs/wave-computer/05-l2-time-metastable-trajectories-working-memory |
| MM1: congruent multimodal cues amplify recall; incongruent cues suppress it (pre-registered) | open | n/a | repro/wave-computer/experiments/MM1_multimodal_amplification/{PREREG.json,mm1_run.py,RESULT.json} |
| MM2: theta locking rescues associative recall lost to frequency dispersion; content still comes from stored couplings | open | n/a | repro/wave-computer/experiments/MM2_theta_locked_hippocampus/{PREREG.json,mm2_run.py,RESULT.json} |
4D DNA Blueprint
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: gamma = -mean nearest-neighbour stacking dG37 (SantaLucia); corr(gamma, GC) = 0.998 | identity | n/a | docs/dna/rb-reading-complete-building-open; docs/dna/02-material-threshold-scale; reviews/dna/2026-09-28_review.md issue A1; recheck here: 2000 random 2501-bp sequences give 0.9997 |
| R19 in biology: spinodal ~ gamma^1.5, barrier gamma^2/4; every locus is bistable (can-fire) | identity | n/a | repro/dna/repro/dna/15-dna-dictionary/build_dictionary.py:43 (r19_bistable = bool(g > 0.0)); reviews/dna/2026-09-28_review.md issues A2, B11 |
| Sequence information beyond GC, A4 shape channel: carries tissue/regulatory identity and helical-face contact | open | helical-face test null | docs/dna/13-unified-deterministic-interpreter (contact_competent at chance, permutation z ~ -0.9; functional decoding [O]); docs/dna/ax-b-tissue-dual-interpreter (open, completion false); docs/dna/ax-d / ax-e (G2 14x) |
| Sequence information beyond GC, CpG channel: promoter CpG depletion is dinucleotide structure (environment writes here); LCT CpG hotspot underlies persistence | interpretation | n/a | repro/dna/repro/dna/09-environment-methylation-layer/cpg_substrate_oe.py; docs/dna/09-environment-methylation-layer; docs/dna/13-unified-deterministic-interpreter |
| Developmental order follows spinodal(gamma) order | independent-prediction | null (no correlation): prediction failed | repro/dna/repro/dna/ax-l-completion-closeout/expected/gate_report.json (L5_depth_beats_gamma; L7 spinodal vs depth 0.0087); docs/dna/rb-reading-complete-building-open |
| Absolute developmental clock: held-out Carnegie stage-days reproduced | anchor-restatement | 0.56 d at chosen CS13 endpoint (CS12: 2.75 d; CS15: 1.62 d) | docs/dna/ax-k-absolute-clock; repro/dna/repro/dna/ax-k-absolute-clock; reviews/dna/2026-09-28_review.md A6 |
| GC1: does the direction of delta-gamma (or A4/CpG) of promoter variants predict the direction of measured expression change? | open | n/a | repro/dna/experiments/GC1_promoter_variant_causal_test/{README.md,PROTOCOL.json} |
Inheritance · RNA & Gene Therapy
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: one switch, two channels - unwritable gamma ruler (SET) + writable A4 coordinate | interpretation | n/a | docs/inheritance/01-*; repro/inheritance/engine/two_channel.py; reviews/biology/2026-09-29_inheritance_review.md F3 |
| Held-out FV5: gamma ordering predicts CRISPRi knockdown resistance (rho>0) | independent-prediction | null: wrong sign, non-significant; GC-partialled rho=0.1259 p=0.43 | docs/inheritance/15-held-out-b-validation-null/; repro/inheritance/engine/feasibility_validation.py |
| FV8: gamma separates GOF vs LOF genes (sign test) | independent-prediction | passes at p=0.027 but only 3/7 GOF on predicted side (10/16 overall) | repro/inheritance/engine/feasibility_validation.py (reviewer rerun matches page) |
| Gene-therapy lever map: edit shifts gamma past gamma*=1.4598 | anchor-restatement | n/a | repro/inheritance/engine/gene_therapy.py:42; lever_map.py:85; review F1 |
| Env-to-germline transmission series (TG5) and imprint escapees survive both erasures | identity | n/a | repro/inheritance/engine/env_to_germline.py, germline_escapee.py; review F2,F4 |
| Paternal/maternal asymmetry 13/13; '18/18 green' scoreboard | identity | n/a | docs/inheritance/16-*, 19; review F4 |
Neural Emergence Chain
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: working memory = f_gamma/f_theta ~ 6-7 | anchor-restatement | band choice spans 4.3-11.6; broad gamma band gives 9.68 | docs/neuro §3, §11; reviews/neuro/2026-09-28_review.md A1 |
| EM2: HH squid axon conduction velocity emerges from measured membrane elements | independent-prediction | -10.6% (PREREG band 15%); HH 1952 hand calc 18.8 | repro/neuro/experiments/EM2_hh_axon_emergence/em2_run.py, RESULT.json, PREREG.json |
| Neuron = R19 + slow recovery (FHN) reduction | interpretation | n/a | docs/neuro; EM2 README 'Reading' |
| Promoter gamma orders organs / DWELL sets size (§12,§17,§20,§23) | open | n/a | docs/neuro §12,17,20,23; review B4 |
| Model gates §10,§13,§14,§18,§22 (fusion curve, lever gain table) | identity | n/a | reviews/neuro/2026-09-28_review.md C7 |
| §2-§8 numbers (19x, 0.65 bits, 17x, 9.4x reflex gain, 3.9x, 123.1) | open | 9.4 above physiological range | review D14 (no reproduction code; neuro_extension missing) |
Felt Cognition
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: memory from waves - brainwave carrier + congruent cues summed in hippocampus | interpretation | n/a (in-model [V mech], pre-registered) | repro/wave-computer/experiments MM1, MM2_theta_locked_hippocampus; reviews/mind/2026-09-28 review |
| Carrier invariance: recall identical for carrier omega 0,1,10,100 (low-frequency thought possible) | identity | n/a | wave-computer L0 (inherited premise); review 'core finding' |
| Frequency dispersion limit / theta-lock window | interpretation | n/a | repro/wave-computer/experiments/MM2_theta_locked_hippocampus |
| Global coherence anchor R ~ 0.39 at measured coupling (euthymia / access window) | anchor-restatement | n/a | docs/mind hub, §14, §29; review |
| WM theta/gamma ~ 6.1 in mind engine | anchor-restatement | tau-dependent 4.4-8.0 | docs/mind §4-§9; review item 3 |
| Gates §48-§50 (K3 L=R/R_anchor, C1, T1), hysteresis=2*spinodal, §29 drive=spinodal(g) | identity | n/a | reviews/mind/2026-09-28 item 2, 9 (tree_ok rewrites constants; pac_grounded defaults True) |
Sensory Organs
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: cochlear Hopf R=(F/beta)^(1/3), exponent 0.333 | identity | 1/3 at top edge of observed range | repro/sensory_organ/.../cochlear_amplifier.py; review R1-2 |
| Small-signal gain ~464 at criticality | anchor-restatement | n/a | cochlear_amplifier.py F_probe=1e-4; review R1-2 |
| Transducer max slope 3.1-3.3 matches Hill ~3 | anchor-restatement | grid 21/41/81/161 -> 2.39/3.32/4.54/6.07 | transduction.py ~l.108-111 (41-point grid); review R1-1 |
| Developmental order argsort(gamma), taste latest confirmed | open | contradicted beyond 'taste latest' bit | vp_sns_engine.py:93-123; review R1-3 |
| Disease relative crossing rates 1.00x...52.46x | anchor-restatement | n/a | repro/_pathology/setpoint_failure.py:65 D_ref=0.25*B0; review R1-4 |
| Classical anchors: reduced eye 22.27 mm, 2.69 D/mm, Greenwood 19.8 Hz-20.7 kHz | identity | n/a | organ_optics.py; review R1-8 |
The Eye
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE (a): single-photon R19 flip; Hill~3 from the cubic | interpretation | conflicts: observed rod response graded, n~1; Hill 2-3 is CNG gating | repro/eye/research/E2-single-photon-switch/run.py; review R1-3 |
| HEADLINE (b): n = sqrt(B/rho ratio); reduced eye 60.06 D / 22.2 mm | anchor-restatement | matches (input) | E3-image-formation/run.py; review R1-5 |
| Red-green is the structurally most fragile axis (M-L margin smallest) | open | ordering flips with 1 nm peak shift; holds 39% under +-2 nm jitter | E9-red-green-dichromacy/run.py; review R1-1 (blocker) |
| 633/532 closure ratio 1.189831; m*sin(chi)*D/lambda = 1 | identity | n/a | docs/eye/e0-carrier; review R1-6 |
| Light/dark adaptation contrast gain -> 1/3 ('Weber-like') | interpretation | consistent with Stevens exponent; not Weber | E10-light-dark-adaptation/run.py; review R1-4 |
| Cone/rod emergence order by spinodal(gamma); size ~ dwell gamma^1.5 | open | n/a | docs/eye hub, E1, E11; review R2-7 |
Hearing & the Ear
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: cube-root cochlear amplification, exponent 0.333333 | identity | 1/3 at/above top of range | repro/ear/volume/tools/vp_numeric_ssot.py (polyfit of inherited settle); review R1-3 |
| EM1: hair-bundle oscillation emerges from molecular elements at reported F_max | independent-prediction | FAIL: quiescent at 50.3 pN (~1 pN outside window); inside window matches observed amplitude/frequency | repro/ear/experiments/EM1_hair_bundle_emergence/em1_run.py, RESULT.json, PREREG(_AMENDMENT).json |
| EM1: local compression exponent from elements | independent-prediction | P3 PASS; P4 (>=0.25 floor) FAIL | em1_run.py RESULT.json P3/P4 |
| Greenwood map reproduced to 2e-16; inverse round-trips | identity | n/a | repro/ear/inherited/vp_sound_wave.py:101; review R1-2 |
| Audible band 19.848 Hz - 20677.07 Hz derived; stiffness ratio ~1e6 | anchor-restatement | n/a | docs/ear/06-audible-band; review R1-5 |
| Compression uniform across frequency | interpretation | contradicted at apex | docs/ear/02-cochlear-amplifier; review R1-4 |
| Emergence order TMC1<PCDH15<CDH23<TMIE by spinodal(gamma) | open | n/a | docs/ear/01-place-and-traveling-wave; review R1-1 |
Olfaction & the Nose
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: smell from R19 switch + measured DNA gamma (transduction switch) | interpretation | n/a | repro/nose/research/E2/run.py; review R1-6 |
| Combinatorial code: nested thermometer reaches 4 of 128 patterns | anchor-restatement | dense sweep gives 8 = N+1 | E1/run.py 8 hand-picked sweep points; review R1-3 |
| Transduction switch ~229x steeper than graded control | anchor-restatement | +-1/5/10% step -> 229/48/24 | E2/run.py l.145-154; review R1-4 |
| CNGB1 gamma=1.4357 byte-identical to rod-vision value | identity | 0 | E2/run.py l.74 hard-codes value; organ_gamma.json both volumes; review R1-5 |
| Congenital anosmia 7/7; allergic sensorineural 0/7 | identity | n/a | E5/run.py l.131-133 (H0=1.15*max h*, damaged=0.90*min h*); review R1-7 |
| Bulb map order EBF1->EMX2->LHX2 forced by gamma; one OR -> one glomerulus bijection | open | conflicts | docs/nose/03-bulb-map; review R1-1, R1-2 |
Cardiorespiratory
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: heart + lung = one FitzHugh-Nagumo oscillator set by measured gamma | interpretation | n/a | repro/cardioresp/repro/_engine/vp_car_engine.py _fhn_rate_arb Neuron(gamma=1.0); review F1 |
| Breathing rate 16.86/min, heart:lung ratio 0.240 'structural, not fitted' | anchor-restatement | in range, but tau_s 60/80/110/130 -> 25.47/19.70/14.76/12.65 | vp_car_engine.py ORGAN_ROWS tau_s=95; review F2 sweep |
| Developmental order lung -> heart from gamma | open | contradicted | review F3 |
| Loop-gain onset at LG=1; RSA lock at f_resp 0.2784 Hz; Cheyne-Stokes T~2*tau (slope 1.992) | identity | model periods 17.7-41.7 s shorter than observed | review F4-F6 |
| Smoking RR 18.3x at 100 pack-years | anchor-restatement | n/a | repro/_oncology/carcinogen_dose_response.py l.193-194 scale=barrier/3; review F8 |
Circulatory Flow & Clearance
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: MAP = CO x SVR; MAP 95.7 | identity | within range (inputs CO,SVR) | repro/circulatory engine; review F6 |
| §9 combined RR matches observed 73 'within 0.000%' | identity | 72.0 vs 73 = -1.4%; the 0.000% is product-of-singles identity | tools/build_docs.py l.420 multiplicativity_dev_pct; RR_COMB_META=73.0; review F2 |
| RR(50 pack-years)=2.00 for RCC | anchor-restatement | 0 (calibration point) | repro/_oncology/carcinogen_dose_response.py D_RCC=0.76645 's.t. RR(50)=2.0'; review F3 |
| Diastolic tau = RC 1.54 s; GFR 125; osmolality 287; PI setpoint return | identity | n/a | review F6 |
| Clearance elasticities 0.90/0.10, 0.91/0.11; KDIGO landing; barrier round-trips | identity | n/a | review F4, F5, F7 |
| Organ order liver -> kidney and size DWELL ~ gamma^1.5 forced | open | agrees (one pair) | docs/circulatory hub, §1; review F1 |
Digestive Transport
| claim | class | residual / result | evidence |
|---|---|---|---|
| HEADLINE: one clock gastric ~3 -> duodenum 11.1 cpm with zero intestinal tuning | anchor-restatement | close to observed, but tau_duo 80..120 -> 12.9..9.0; T=6000 -> 12.0; ISI 10.99 | repro/digestive vp_dig_engine.py TAU_DUO=95, GRAD_FACTOR=1.5, FFT window T=8000; review F2,F3 |
| Gastric slow wave 3.0 cpm | anchor-restatement | 0 by definition | vp_dig_engine.py l.79 K_TIME=3/f(tau_s=380); review F4 |
| Developmental order intestine, pancreas, liver, stomach forced [V], sign-validated | open | contradicted | vp_dig_engine.py l.197,212 (label string only); review F1 |
| Aboral transport direction; glucose setpoint return | identity | n/a | review F5 |
| Disease RRs via R19 gates (§7-§30) | anchor-restatement | n/a | review F6 |
Musculoskeletal Load
| claim | class | residual / result | evidence |
|---|---|---|---|
| Headline: structure + mechanical load read from measured promoter γ | interpretation | reviews/biology/2026-09-29_musculoskeletal_review.md Summary; repro/musculoskeletal/repro/vp_msk_dynamics.py | |
| γ-rank reproduces limb→cartilage→muscle developmental order | interpretation | conflicts: somitic myogenesis precedes limb Sox9; pass uses 3 of 4 genes (RUNX2 excluded), 1 of 6 orders | reviews/biology/2026-09-29_musculoskeletal_review.md F1; vp_msk_dynamics.py T4 l.241-268 |
| Tetanic fusion at 25 Hz (tracks 1/τ) | anchor-restatement | 25 Hz is grid/criterion artefact: 22 Hz on 1 Hz grid; 32/15 Hz at 0.05/0.20 ripple criterion | reviews/biology/2026-09-29_musculoskeletal_review.md F2; vp_msk_dynamics.py T1 |
| Fatigue time constant and recovery | anchor-restatement | τ recovers the 60 s input; loss = 0.55·(1−e^-3); recovery depends on 180 s window (81/93/99.7% at 60/120/300 s) | reviews/biology/2026-09-29_musculoskeletal_review.md F3; vp_msk_dynamics.py T5 |
| Wolff/bone-yield threshold = spinodal of cubic | identity | reviews/biology/2026-09-29_musculoskeletal_review.md F4; vp_msk_dynamics.py T3 |
Immune & Hematologic
| claim | class | residual / result | evidence |
|---|---|---|---|
| Headline: population thresholds on the R19 switch read from measured γ | interpretation | 0 (sequence provenance check) | reviews/biology/2026-09-29_immune_hematologic_review.md Summary, F5 |
| Lineage order from γ ranking; 'endpoints match embryology' | interpretation | conflicts with observed site sequence | reviews/biology/2026-09-29_immune_hematologic_review.md F1; docs/immune_hematologic/03-developmental-lineage-order-gamma-readout/ |
| Shared-drive race confirms order dynamically | identity | reviews/biology/2026-09-29_immune_hematologic_review.md F2; _dynamics/lineage_order.py | |
| Optimal re-boost interval emerges at measured half-life | identity | reviews/biology/2026-09-29_immune_hematologic_review.md F3; _dynamics/emergent_durable_boost.py l.23,105 | |
| Thymic involution raises escape, lowers naive export | interpretation | reviews/biology/2026-09-29_immune_hematologic_review.md Summary; _dynamics/emergent_immunosenescence.py |
Integumentary Barrier
| claim | class | residual / result | evidence |
|---|---|---|---|
| Headline: barrier + external stimulus; UV → melanoma key | interpretation | reviews/biology/2026-09-29_integumentary_review.md Summary; repro/integumentary run_all.py (2×sha256 identical) | |
| Developmental order epidermis→appendage→melanocyte→keratinocyte from γ | interpretation | conflicts: keratinocyte ranked last | reviews/biology/2026-09-29_integumentary_review.md F1 |
| Epidermal turnover ~28 d lands in cited 28-40 d window | identity | reviews/biology/2026-09-29_integumentary_review.md F2; _engine/skn_dynamics.py l.238-244 | |
| Intermittent-burst UV raises melanoma RR | independent-prediction | direction matches; magnitude overshoots (~3.5×); input-dependent: 2.2/5.7/7.0 at cumulative 4/6/8 | reviews/biology/2026-09-29_integumentary_review.md F3; _oncology/carcinogen_dose_response.py |
| Occlusion/adhesion set-points [F] forced (substrate) | identity | reviews/biology/2026-09-29_integumentary_review.md F4 |
Reproductive & Endocrine
| claim | class | residual / result | evidence |
|---|---|---|---|
| Headline: four organs read from measured γ; organ order germline→testis→ovary→tract | interpretation | conflicts (WT1 ranked last); testis vs ovary rank has no observable counterpart | reviews/biology/2026-09-29_reproductive_endocrine_review.md F1; docs/reproductive_endocrine/02-organ-emergence-measured-gamma/ |
| Embryo body-plan order from γ | independent-prediction | weak ρ on coarse ranks; gene-level conflicts; dna §AX-A γ-order test returned null | reviews/biology/2026-09-29_reproductive_endocrine_review.md F2; _embryo/embryogenesis.run_E4 |
| Spermatogenic vs menstrual = one oscillator at two speeds | anchor-restatement | reviews/biology/2026-09-29_reproductive_endocrine_review.md F3; spermatogenesis.py | |
| Breast-cancer RR plateau under hormone exposure | anchor-restatement | code gives 2.07 at 5 y, 3.63 at 10 y; stated anchor not reproduced | reviews/biology/2026-09-29_reproductive_endocrine_review.md F4; _oncology/carcinogen_dose_response.breast_duration_curve |
| BAT selectivity of temporal (cycled) pattern | interpretation | ~27/13.6/6.7× at period 4/8/16 | reviews/biology/2026-09-29_reproductive_endocrine_review.md F5; _therapy/temporal_pattern.bat_selectivity |
| HPG/menstrual/spermatogenic dynamics use measured γ | interpretation | reviews/biology/2026-09-29_reproductive_endocrine_review.md F6 |
Thermometabolic Homeostasis
| claim | class | residual / result | evidence |
|---|---|---|---|
| Headline: endotherm 0.054 vs ectotherm 1.394 setpoint sensitivity | anchor-restatement | g_endo 1.0→0.107; g_ecto 0.30→1.246; drive 0.20→0.033/1.309 | reviews/biology/2026-09-29_homeostasis_thermometabolic_review.md F1; repro/homeostasis_thermometabolic/repro/_engine/endotherm_ectotherm.py setpoint_defense_sweep(g_endo=1.40,g_ecto=0.18) |
| Torpor hysteresis loop width | identity | exact 2·h_sp=1.275; grid gives 1.32/1.30/1.29/1.28 | reviews/biology/2026-09-29_homeostasis_thermometabolic_review.md F2; vp_trm_engine.py torpor_hysteresis_sweep |
| 16/16 stress targets pass | identity | reviews/biology/2026-09-29_homeostasis_thermometabolic_review.md F3 | |
| γ does not separate endo/ecto, nor mark hibernation (four nulls) | independent-prediction | null result (group gaps = GC gaps) | reviews/biology/2026-09-29_homeostasis_thermometabolic_review.md F4; docs/homeostasis_thermometabolic/ null pages |
Hemodynamic Homeostasis
| claim | class | residual / result | evidence |
|---|---|---|---|
| Headline: MAP = CVP + CO×SVR = 93 mmHg, error 0 | identity | 0 by construction | reviews/biology/2026-09-29_homeostasis_hemodynamic_review.md F2; _engine/vp_hmd_loops.py SVR_REST_PRU=17.8=(93−4)/5 |
| Hypertension reset and therapy: durable vs transient BP lowering | anchor-restatement | output equals chosen input ref_reset (varies 1:1) | reviews/biology/2026-09-29_homeostasis_hemodynamic_review.md F1; _therapy/fundamental_targets.py hypertension_therapies(reset_up,op_drug,ref_reset) |
| Baroreflex residual fraction | anchor-restatement | reviews/biology/2026-09-29_homeostasis_hemodynamic_review.md F3; rp2_baroreflex() | |
| Perfect adaptation of integral controller (spread 0) | identity | reviews/biology/2026-09-29_homeostasis_hemodynamic_review.md F3 | |
| Heart-failure margin sign | interpretation | reviews/biology/2026-09-29_homeostasis_hemodynamic_review.md Summary | |
| Node identity fixed by master-gene γ; kidney order from DNA | interpretation | reviews/biology/2026-09-29_homeostasis_hemodynamic_review.md F4 | |
| Comfort proposal and prioritisation ([F]) | interpretation | reviews/biology/2026-09-29_homeostasis_hemodynamic_review.md F5 |
Ionic Homeostasis
| claim | class | residual / result | evidence |
|---|---|---|---|
| Headline: mineral / acid-base / electrolyte setpoints; identity and order from measured master-gene γ | interpretation | reviews/biology/2026-09-29_homeostasis_ionic_review.md F1 | |
| OU setpoint laws (Var·2k/σ²=1, error·k=1, zero integral error) | identity | reviews/biology/2026-09-29_homeostasis_ionic_review.md F3; repro/homeostasis_ionic/repro/_engine/vp_loops.py | |
| Winters compensation slope | anchor-restatement | 1.10 below cited range; code gate accepts 1.0-1.6 | reviews/biology/2026-09-29_homeostasis_ionic_review.md F2; vp_loops.py ri2_acidbase (pCO2*=40·(HCO3/24)^0.6) |
| Calcium setpoint loop return | interpretation | reviews/biology/2026-09-29_homeostasis_ionic_review.md F4; vp_loops.py ri1_calcium | |
| ATP1A1 promoter γ does not order species by loop gain | independent-prediction | null | reviews/biology/2026-09-29_homeostasis_ionic_review.md Summary; docs/homeostasis_ionic §13 |
Circadian Oscillator
| claim | class | residual / result | evidence |
|---|---|---|---|
| Headline: measured BMAL1/ARNTL γ = 1.33348 seeds the clock | interpretation | recomputes bit-for-bit | reviews/biology/2026-09-29_circadian_review.md Summary, F1; repro/circadian/repro/_engine/vp_clk_engine.py l.116-295 |
| Free-running oscillation precision | interpretation | reviews/biology/2026-09-29_circadian_review.md Summary | |
| Entrainment PRC and Arnold tongue | interpretation | tongue saturates at sweep size (15/15) | reviews/biology/2026-09-29_circadian_review.md F5 |
| Jet-lag re-entrainment ~1 h/day PRC-bounded | anchor-restatement | reviews/biology/2026-09-29_circadian_review.md F2; max_shift_per_cycle=1.0 | |
| Chronotherapy: light and melatonin act in antiphase | anchor-restatement | reviews/biology/2026-09-29_circadian_review.md F3 | |
| Gating ablation, misalignment and flattening indices | identity | reviews/biology/2026-09-29_circadian_review.md F4 |
Aging & Senescence
| claim | class | residual / result | evidence |
|---|---|---|---|
| Headline: human aging genes not special in promoter γ | independent-prediction | null (z includes human value) | reviews/biology/2026-09-29_aging_senescence_review.md Summary, F8; repro/aging_senescence/repro/_engine/xspecies_discriminant.py discriminant() |
| Cancer incidence rise with age | anchor-restatement | 25.0/52.3/107.9× at 5/6/7 stages | reviews/biology/2026-09-29_aging_senescence_review.md F1; _engine/aging_dynamics.py RA5 (stages=6) |
| Barrier-shrink hazard ratio (§12) | anchor-restatement | ~18000/135/12× at T 0.05/0.1/0.2 | reviews/biology/2026-09-29_aging_senescence_review.md F1 |
| One aging axis (PCA-1 share, §8) | anchor-restatement | 0.986/0.889/0.682 at noise 0.05/0.15/0.30 | reviews/biology/2026-09-29_aging_senescence_review.md F1 |
| Senescence fraction (§4) | anchor-restatement | 0.224/0.391/0.625 at base hazard 0.006/0.012/0.024 | reviews/biology/2026-09-29_aging_senescence_review.md F1 |
| Depletion steps, hallmark coverage, telomere-repeat γ | identity | reviews/biology/2026-09-29_aging_senescence_review.md F2 | |
| Lifespan span of γ panel | open | data span is 3.8-122.5 yr (~32-fold); bowhead has no γ | reviews/biology/2026-09-29_aging_senescence_review.md F3 |
Analgesic Threshold Logic
| claim | class | residual / result | evidence |
|---|---|---|---|
| Headline: three levers L1/L2/L3 from 27 nociception gene γ/|h_sp| | interpretation | 0 mismatches page vs code | reviews/biology/2026-09-29_analgesic_threshold_review.md R1; repro/analgesic_threshold/03-threshold-map/expected/threshold_map.json |
| corr(γ,GC) = 0.99898 | identity | reviews/biology/2026-09-29_analgesic_threshold_review.md R1,R2; 02 nav_gate.json | |
| |h_sp| and barrier per gene | identity | reviews/biology/2026-09-29_analgesic_threshold_review.md R2 | |
| Target prioritisation | anchor-restatement | reviews/biology/2026-09-29_analgesic_threshold_review.md R1 | |
| Proposals P1-P6 (e.g. differential block) | interpretation | reviews/biology/2026-09-29_analgesic_threshold_review.md R1 | |
| Volume gate | open | claim_scan hash drift: scanner misses moved docs/ | reviews/biology/2026-09-29_analgesic_threshold_review.md R2 |
Rare Disease Mechanisms (Cases)
| claim | class | residual / result | evidence |
|---|---|---|---|
| Headline: burden = raw_burden·(1−e) residual ranking | anchor-restatement | byte-identical rerun; order moves under reweighting (ρ 0.89-0.98) | reviews/biology/2026-09-29_disease_wp_review.md R1,R2; repro/disease_wp r15_severity_litcurate.py |
| Per-disease gene-key mechanism cases | interpretation | reviews/biology/2026-09-29_disease_wp_review.md R1 | |
| Mechanism-class grouping (pages 37,38) [F] | interpretation | reviews/biology/2026-09-29_disease_wp_review.md R1 | |
| Pipeline gate | open | prior_round_artifacts_preserved FAIL (R9-R14 digest drift) | reviews/biology/2026-09-29_disease_wp_review.md R2 r15_gate.py |
Rare Disease Reproduction KIT
| claim | class | residual / result | evidence |
|---|---|---|---|
| Headline: per-disease corrective direction, magnitude [O] | interpretation | reviews/biology/2026-09-29_disease_kit_review.md R1; repro/disease_kit pipeline/treatment_switch.py (sign = −DIRINT[axis]) | |
| Recovery of standard of care as validation | identity | reviews/biology/2026-09-29_disease_kit_review.md R1 | |
| R19 cusp geometry per disease (e.g. AADC) | identity | reviews/biology/2026-09-29_disease_kit_review.md R1,R2; diseases/aadc_deficiency/analysis.json | |
| Reproducibility of site release 0.42.1 | open | ~750 pages lack reproduction path (package v0.32) | reviews/biology/2026-09-29_disease_kit_review.md R2 |